Microwave-assisted synthesis and antimicrobial activities of flavonoid derivatives
Microwave-assisted synthesis and antimicrobial activities of flavonoid derivatives
Eleven flavonoid derivatives were synthesised using a modified Baker–Venkataraman rearrangement, and subsequent microwave-assisted closure of the heterocyclic ring. All of the synthetic compounds displayed antifungal activity against Aspergillus niger and Fusarium oxysporium, and two of the synthetic flavonoid analogues exhibited significant activity against methicillin-resistant Staphylococcus aureus.
copper, flavonoids, resistance, antifungal, antibacterial activity, drinking-water, invasive aspergillosis, bacteria, antibacterial, organic-synthesis, binding
518-522
Abdel Ghani, Sherif B.
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Weaver, Louise
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Zidan, Zidan H.
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Ali, Hussein M.
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Keevil, C. William
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Brown, Richard C.D.
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15 January 2008
Abdel Ghani, Sherif B.
9b8b6bd8-47cd-4268-bfb3-4de0677fb896
Weaver, Louise
09df22f5-0bd0-468d-aad5-93d16a25afc9
Zidan, Zidan H.
3549ed4b-7aaa-4dae-9dd9-0d2d467efc5e
Ali, Hussein M.
d258cd4b-b98f-4f3d-a2d9-38a6a7de90b9
Keevil, C. William
cb7de0a7-ce33-4cfa-af52-07f99e5650eb
Brown, Richard C.D.
21ce697a-7c3a-480e-919f-429a3d8550f5
Abdel Ghani, Sherif B., Weaver, Louise, Zidan, Zidan H., Ali, Hussein M., Keevil, C. William and Brown, Richard C.D.
(2008)
Microwave-assisted synthesis and antimicrobial activities of flavonoid derivatives.
Bioorganic & Medicinal Chemistry Letters, 18 (2), .
(doi:10.1016/j.bmcl.2007.11.081).
Abstract
Eleven flavonoid derivatives were synthesised using a modified Baker–Venkataraman rearrangement, and subsequent microwave-assisted closure of the heterocyclic ring. All of the synthetic compounds displayed antifungal activity against Aspergillus niger and Fusarium oxysporium, and two of the synthetic flavonoid analogues exhibited significant activity against methicillin-resistant Staphylococcus aureus.
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e-pub ahead of print date: 28 November 2007
Published date: 15 January 2008
Keywords:
copper, flavonoids, resistance, antifungal, antibacterial activity, drinking-water, invasive aspergillosis, bacteria, antibacterial, organic-synthesis, binding
Identifiers
Local EPrints ID: 54458
URI: http://eprints.soton.ac.uk/id/eprint/54458
PURE UUID: b9228d9e-a782-41a8-b72d-37e408787c36
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Date deposited: 19 Aug 2008
Last modified: 16 Mar 2024 03:24
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Contributors
Author:
Sherif B. Abdel Ghani
Author:
Louise Weaver
Author:
Zidan H. Zidan
Author:
Hussein M. Ali
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