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Microwave-assisted synthesis and antimicrobial activities of flavonoid derivatives

Microwave-assisted synthesis and antimicrobial activities of flavonoid derivatives
Microwave-assisted synthesis and antimicrobial activities of flavonoid derivatives
Eleven flavonoid derivatives were synthesised using a modified Baker–Venkataraman rearrangement, and subsequent microwave-assisted closure of the heterocyclic ring. All of the synthetic compounds displayed antifungal activity against Aspergillus niger and Fusarium oxysporium, and two of the synthetic flavonoid analogues exhibited significant activity against methicillin-resistant Staphylococcus aureus.
copper, flavonoids, resistance, antifungal, antibacterial activity, drinking-water, invasive aspergillosis, bacteria, antibacterial, organic-synthesis, binding
518-522
Abdel Ghani, Sherif B.
9b8b6bd8-47cd-4268-bfb3-4de0677fb896
Weaver, Louise
09df22f5-0bd0-468d-aad5-93d16a25afc9
Zidan, Zidan H.
3549ed4b-7aaa-4dae-9dd9-0d2d467efc5e
Ali, Hussein M.
d258cd4b-b98f-4f3d-a2d9-38a6a7de90b9
Keevil, C. William
e381d726-ddae-4bfc-955e-5201d31f4e5d
Brown, Richard C.D.
21ce697a-7c3a-480e-919f-429a3d8550f5
Abdel Ghani, Sherif B.
9b8b6bd8-47cd-4268-bfb3-4de0677fb896
Weaver, Louise
09df22f5-0bd0-468d-aad5-93d16a25afc9
Zidan, Zidan H.
3549ed4b-7aaa-4dae-9dd9-0d2d467efc5e
Ali, Hussein M.
d258cd4b-b98f-4f3d-a2d9-38a6a7de90b9
Keevil, C. William
e381d726-ddae-4bfc-955e-5201d31f4e5d
Brown, Richard C.D.
21ce697a-7c3a-480e-919f-429a3d8550f5

Abdel Ghani, Sherif B., Weaver, Louise, Zidan, Zidan H., Ali, Hussein M., Keevil, C. William and Brown, Richard C.D. (2008) Microwave-assisted synthesis and antimicrobial activities of flavonoid derivatives. Bioorganic & Medicinal Chemistry Letters, 18 (2), 518-522. (doi:10.1016/j.bmcl.2007.11.081).

Record type: Article

Abstract

Eleven flavonoid derivatives were synthesised using a modified Baker–Venkataraman rearrangement, and subsequent microwave-assisted closure of the heterocyclic ring. All of the synthetic compounds displayed antifungal activity against Aspergillus niger and Fusarium oxysporium, and two of the synthetic flavonoid analogues exhibited significant activity against methicillin-resistant Staphylococcus aureus.

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More information

e-pub ahead of print date: 28 November 2007
Published date: 15 January 2008
Keywords: copper, flavonoids, resistance, antifungal, antibacterial activity, drinking-water, invasive aspergillosis, bacteria, antibacterial, organic-synthesis, binding

Identifiers

Local EPrints ID: 54458
URI: https://eprints.soton.ac.uk/id/eprint/54458
PURE UUID: b9228d9e-a782-41a8-b72d-37e408787c36
ORCID for Richard C.D. Brown: ORCID iD orcid.org/0000-0003-0156-7087

Catalogue record

Date deposited: 19 Aug 2008
Last modified: 14 Mar 2019 01:51

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