The University of Southampton
University of Southampton Institutional Repository

Parent of origin effects in attention/deficit hyperactivity disorder (ADHD): analysis of data from the international multicentre ADHD genetics (IMAGE) programme.

Parent of origin effects in attention/deficit hyperactivity disorder (ADHD): analysis of data from the international multicentre ADHD genetics (IMAGE) programme.
Parent of origin effects in attention/deficit hyperactivity disorder (ADHD): analysis of data from the international multicentre ADHD genetics (IMAGE) programme.
There are conflicting reports suggesting that the parental origin of transmitted risk alleles may play a role in the etiology of attention deficit/hyperactivity disorder (ADHD). A recent report by Hawi and colleagues observed a generalized paternal over-transmission of alleles associated with ADHD. This was not replicated in more recent studies. Using data from a large multicenter study we examined the overall and gene-specific parent of origin effect in 554 independent SNPs across 47 genes. Transmission disequilibrium and explicit parent of origin test were performed using PLINK. Overall parent of origin effect was tested by Chi-square. There was no overall parent of origin effect in the IMAGE sample (, P = 0.117). Five markers in three genes, DDC, TPH2, and SLC6A2 showed nominal association (P < 0.01) with ADHD combined subtype when restricted to maternal or paternal transmission only. Following the initial report by Hawi and co-workers three studies, including this one, found no evidence to support an overall parent of origin effect for markers associated with ADHD. We cannot however, exclude gene-specific parent of origin effect in the etiology ADHD. © 2007 Wiley-Liss, Inc.
ADHD • candidate gene • parent of origin effect
1552-4841
Anney, Richard J.L.
2791ef41-5a38-43b2-862a-95700abb6432
Hawi, Ziarih
4e5ba3c6-def0-4901-be50-21d332ea7900
Sheehan, Karen
d8ad29d4-2259-480e-bd34-97502fca3f23
Mulligan, Aisling
79696570-6acc-4f76-bdfa-2854c134c531
Pinto, Carlos
7e769477-1739-4752-9a39-f2280768ed9b
Brookes, Keeley J.
ab1dd287-11d8-4c0b-8616-e362d61a2d7c
Xu, Xiaohui
748c2168-7f27-447b-927b-497614387141
Zhou, Kaixin
8ba67199-61d7-47d8-ba5b-635c24fc696a
Franke, Barbara
f71c8989-a108-40c4-a159-80a1e60b56bf
Buitelaar, Jan
0a7a93a0-884f-4fe1-9cd8-6c9f9c5df4da
Vermeulen, Sita H.
18e6cf6c-3099-43ed-9e02-758875aeabad
Banaschewski, Tobias
4627c589-04cc-4f5b-ac2d-05f547f63dfd
Sonuga-Barke, Edmund
bc80bf95-6cf9-4c76-a09d-eaaf0b717635
Ebstein, Richard
61f78327-53b0-453d-8b2a-1a5363ebff67
Manor, Iris
786b2370-0f31-4448-a3b3-484204b3b7e2
Miranda, Ana
e416878c-5ff3-4892-bb8f-17e8de0884ac
Mulas, Fernando
24e7867d-0808-4de7-9b63-831f8ff79f6f
Oades, Robert.D.
124012cd-54bb-4bfa-bbd7-b02185d9c44c
Roeyers, Herbert
3554b6b3-e364-4a6a-9e8b-64f5188a6d60
Rommelse, Nanda
3b0bb74c-f8d0-4515-9e01-fd33ce82fef1
Rothenberger, Aribert
736981ca-a16d-44b3-8312-2067dc792a6d
Sergeant, Joseph
9d13c879-0b3b-45df-8ba7-3978ca029ac5
Steinhausen, Hans-Christoph
991ad7f9-c5d1-4c61-8118-3d4895d2706d
Taylor, Eric
0df56dc7-9553-44e2-9594-612d758f8684
Thompson, Margaret
bfe8522c-b252-4771-8036-744e93357c67
Asherson, Philip
a734c1f6-f31a-450b-81c3-ba7bb373e147
Faraone, Stephen.V.
459e29d2-a72a-4cff-b92e-33d5cbeaa8f0
Gill, Michael
408d1dfa-5205-4e50-8130-7b26aa8288e8
Anney, Richard J.L.
2791ef41-5a38-43b2-862a-95700abb6432
Hawi, Ziarih
4e5ba3c6-def0-4901-be50-21d332ea7900
Sheehan, Karen
d8ad29d4-2259-480e-bd34-97502fca3f23
Mulligan, Aisling
79696570-6acc-4f76-bdfa-2854c134c531
Pinto, Carlos
7e769477-1739-4752-9a39-f2280768ed9b
Brookes, Keeley J.
ab1dd287-11d8-4c0b-8616-e362d61a2d7c
Xu, Xiaohui
748c2168-7f27-447b-927b-497614387141
Zhou, Kaixin
8ba67199-61d7-47d8-ba5b-635c24fc696a
Franke, Barbara
f71c8989-a108-40c4-a159-80a1e60b56bf
Buitelaar, Jan
0a7a93a0-884f-4fe1-9cd8-6c9f9c5df4da
Vermeulen, Sita H.
18e6cf6c-3099-43ed-9e02-758875aeabad
Banaschewski, Tobias
4627c589-04cc-4f5b-ac2d-05f547f63dfd
Sonuga-Barke, Edmund
bc80bf95-6cf9-4c76-a09d-eaaf0b717635
Ebstein, Richard
61f78327-53b0-453d-8b2a-1a5363ebff67
Manor, Iris
786b2370-0f31-4448-a3b3-484204b3b7e2
Miranda, Ana
e416878c-5ff3-4892-bb8f-17e8de0884ac
Mulas, Fernando
24e7867d-0808-4de7-9b63-831f8ff79f6f
Oades, Robert.D.
124012cd-54bb-4bfa-bbd7-b02185d9c44c
Roeyers, Herbert
3554b6b3-e364-4a6a-9e8b-64f5188a6d60
Rommelse, Nanda
3b0bb74c-f8d0-4515-9e01-fd33ce82fef1
Rothenberger, Aribert
736981ca-a16d-44b3-8312-2067dc792a6d
Sergeant, Joseph
9d13c879-0b3b-45df-8ba7-3978ca029ac5
Steinhausen, Hans-Christoph
991ad7f9-c5d1-4c61-8118-3d4895d2706d
Taylor, Eric
0df56dc7-9553-44e2-9594-612d758f8684
Thompson, Margaret
bfe8522c-b252-4771-8036-744e93357c67
Asherson, Philip
a734c1f6-f31a-450b-81c3-ba7bb373e147
Faraone, Stephen.V.
459e29d2-a72a-4cff-b92e-33d5cbeaa8f0
Gill, Michael
408d1dfa-5205-4e50-8130-7b26aa8288e8

Anney, Richard J.L., Hawi, Ziarih, Sheehan, Karen, Mulligan, Aisling, Pinto, Carlos, Brookes, Keeley J., Xu, Xiaohui, Zhou, Kaixin, Franke, Barbara, Buitelaar, Jan, Vermeulen, Sita H., Banaschewski, Tobias, Sonuga-Barke, Edmund, Ebstein, Richard, Manor, Iris, Miranda, Ana, Mulas, Fernando, Oades, Robert.D., Roeyers, Herbert, Rommelse, Nanda, Rothenberger, Aribert, Sergeant, Joseph, Steinhausen, Hans-Christoph, Taylor, Eric, Thompson, Margaret, Asherson, Philip, Faraone, Stephen.V. and Gill, Michael (2008) Parent of origin effects in attention/deficit hyperactivity disorder (ADHD): analysis of data from the international multicentre ADHD genetics (IMAGE) programme. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics. (doi:10.1002/ajmg.b.30659).

Record type: Article

Abstract

There are conflicting reports suggesting that the parental origin of transmitted risk alleles may play a role in the etiology of attention deficit/hyperactivity disorder (ADHD). A recent report by Hawi and colleagues observed a generalized paternal over-transmission of alleles associated with ADHD. This was not replicated in more recent studies. Using data from a large multicenter study we examined the overall and gene-specific parent of origin effect in 554 independent SNPs across 47 genes. Transmission disequilibrium and explicit parent of origin test were performed using PLINK. Overall parent of origin effect was tested by Chi-square. There was no overall parent of origin effect in the IMAGE sample (, P = 0.117). Five markers in three genes, DDC, TPH2, and SLC6A2 showed nominal association (P < 0.01) with ADHD combined subtype when restricted to maternal or paternal transmission only. Following the initial report by Hawi and co-workers three studies, including this one, found no evidence to support an overall parent of origin effect for markers associated with ADHD. We cannot however, exclude gene-specific parent of origin effect in the etiology ADHD. © 2007 Wiley-Liss, Inc.

Full text not available from this repository.

More information

Published date: 2008
Keywords: ADHD • candidate gene • parent of origin effect

Identifiers

Local EPrints ID: 54874
URI: https://eprints.soton.ac.uk/id/eprint/54874
ISSN: 1552-4841
PURE UUID: 4459b91e-51a3-4130-9024-9b417d682ff6

Catalogue record

Date deposited: 29 Jul 2008
Last modified: 13 Mar 2019 20:37

Export record

Altmetrics

Contributors

Author: Richard J.L. Anney
Author: Ziarih Hawi
Author: Karen Sheehan
Author: Aisling Mulligan
Author: Carlos Pinto
Author: Keeley J. Brookes
Author: Xiaohui Xu
Author: Kaixin Zhou
Author: Barbara Franke
Author: Jan Buitelaar
Author: Sita H. Vermeulen
Author: Tobias Banaschewski
Author: Edmund Sonuga-Barke
Author: Richard Ebstein
Author: Iris Manor
Author: Ana Miranda
Author: Fernando Mulas
Author: Robert.D. Oades
Author: Herbert Roeyers
Author: Nanda Rommelse
Author: Aribert Rothenberger
Author: Joseph Sergeant
Author: Hans-Christoph Steinhausen
Author: Eric Taylor
Author: Margaret Thompson
Author: Philip Asherson
Author: Stephen.V. Faraone
Author: Michael Gill

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×