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Learning modulation by endogenous hippocampal IL-1: Blockade of endogenous IL-1 facilitates memory formation

Learning modulation by endogenous hippocampal IL-1: Blockade of endogenous IL-1 facilitates memory formation
Learning modulation by endogenous hippocampal IL-1: Blockade of endogenous IL-1 facilitates memory formation
The interleukin-1 (IL-1) cytokine family (IL-1, IL-, and the IL-1 receptor antagonist) is involved in immune and inflammatory responses both in the brain and in the periphery. Recently, it has also been shown to influence behavior and memory consolidation. However, within the experimental systems studied, it has remained unclear whether the role of IL-1 is associated solely with a pathophysiological process or whether it is a neuromodulator in normal adult brain. To evaluate the involvement of the nonpathological endogenous IL-1 system in learning, we studied the expression of IL-1, IL-1, and IL-1ra during memory consolidation. We observed a learning-specific hippocampal IL-1 mRNA induction, but not that of IL-1 or IL-1ra mRNAs, after inhibitory avoidance training. Moreover, when IL-1 receptor activity was inhibited using an adenoviral vector that expresses the IL-1 receptor antagonist (IL-1ra) in the hippocampus, both short-term and long-term memory retention scores were facilitated. In contrast, endogenous hippocampal IL-1 played no role in the habituation to a novel environment. These results demonstrate that endogenous hippocampal IL-1 specifically modulates a fear-motivated learning task, and suggest that IL-1 activity in the CNS is part of the hippocampal memory processing.
memory consolidation, inhibitory avoidance learning, open-field habituation, interleukin-1 receptor antagonist, competitive RT-PCR
1050-9631
526-535
Depino, Amaicha M.
b14c0d5b-9594-44a3-a422-acced1f281b2
Alonso, Mariana
5dbe0b5a-244b-4ecf-895f-f83d3766ae83
Ferrari, Carina
f0868e34-6d38-4a37-8b7c-f8eee8111f9e
del Ray, Adriana
645c0622-15c8-46f1-b4a7-d10614502155
Anthony, Daniel
028be736-8583-4fe7-964e-9b11b40165d1
Besedovsky, Hugo
3177f7ec-aed8-49c2-bb8d-8a47861b083c
Medina, Jorge H.
99f17899-33f0-435e-9509-d530b229a8c0
Pitossi, Fernando
b5e78a06-f2de-4ce9-b310-d116017a665d
Depino, Amaicha M.
b14c0d5b-9594-44a3-a422-acced1f281b2
Alonso, Mariana
5dbe0b5a-244b-4ecf-895f-f83d3766ae83
Ferrari, Carina
f0868e34-6d38-4a37-8b7c-f8eee8111f9e
del Ray, Adriana
645c0622-15c8-46f1-b4a7-d10614502155
Anthony, Daniel
028be736-8583-4fe7-964e-9b11b40165d1
Besedovsky, Hugo
3177f7ec-aed8-49c2-bb8d-8a47861b083c
Medina, Jorge H.
99f17899-33f0-435e-9509-d530b229a8c0
Pitossi, Fernando
b5e78a06-f2de-4ce9-b310-d116017a665d

Depino, Amaicha M., Alonso, Mariana, Ferrari, Carina, del Ray, Adriana, Anthony, Daniel, Besedovsky, Hugo, Medina, Jorge H. and Pitossi, Fernando (2003) Learning modulation by endogenous hippocampal IL-1: Blockade of endogenous IL-1 facilitates memory formation. Hippocampus, 14 (4), 526-535. (doi:10.1002/hipo.10164).

Record type: Article

Abstract

The interleukin-1 (IL-1) cytokine family (IL-1, IL-, and the IL-1 receptor antagonist) is involved in immune and inflammatory responses both in the brain and in the periphery. Recently, it has also been shown to influence behavior and memory consolidation. However, within the experimental systems studied, it has remained unclear whether the role of IL-1 is associated solely with a pathophysiological process or whether it is a neuromodulator in normal adult brain. To evaluate the involvement of the nonpathological endogenous IL-1 system in learning, we studied the expression of IL-1, IL-1, and IL-1ra during memory consolidation. We observed a learning-specific hippocampal IL-1 mRNA induction, but not that of IL-1 or IL-1ra mRNAs, after inhibitory avoidance training. Moreover, when IL-1 receptor activity was inhibited using an adenoviral vector that expresses the IL-1 receptor antagonist (IL-1ra) in the hippocampus, both short-term and long-term memory retention scores were facilitated. In contrast, endogenous hippocampal IL-1 played no role in the habituation to a novel environment. These results demonstrate that endogenous hippocampal IL-1 specifically modulates a fear-motivated learning task, and suggest that IL-1 activity in the CNS is part of the hippocampal memory processing.

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More information

Submitted date: 11 March 2003
Published date: 20 November 2003
Keywords: memory consolidation, inhibitory avoidance learning, open-field habituation, interleukin-1 receptor antagonist, competitive RT-PCR

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Local EPrints ID: 55561
URI: https://eprints.soton.ac.uk/id/eprint/55561
ISSN: 1050-9631
PURE UUID: e7e5117e-9fcd-4c23-afbc-c3df3641d67b

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Date deposited: 01 Aug 2008
Last modified: 13 Mar 2019 20:36

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Contributors

Author: Amaicha M. Depino
Author: Mariana Alonso
Author: Carina Ferrari
Author: Adriana del Ray
Author: Daniel Anthony
Author: Hugo Besedovsky
Author: Jorge H. Medina
Author: Fernando Pitossi

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