Fish as bioreactors: transgene expression of human coagulation factor VII in fish embryos


Hwang, Gyulin, Muller, Ferenc, Rahman, M. Aziz, Williams, Darren W., Murdock, Paul J., Pasi, K. John, Goldspink, Geoffrey, Farahmand, Hamid and Maclean, Norman (2004) Fish as bioreactors: transgene expression of human coagulation factor VII in fish embryos Marine Biotechnology, 6, (5), pp. 485-492. (doi:10.1007/s10126-004-3121-2).

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Description/Abstract

A plasmid containing human coagulation factor VII (hFVII) complementary DNA regulated by a cytomegalovirus promoter was microinjected into fertilized eggs of zebrafish, African catfish, and tilapia. The active form of hFVll was detected in the fish embryos by various assays. This positive expression of human therapeutic protein in fish embryos demonstrates the possibility of exploitation of transgenic fish as bioreactors.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1007/s10126-004-3121-2
ISSNs: 1436-2228 (print)
Keywords: human coagulation factor VII, transgenic fish, bioreactor
Subjects:
ePrint ID: 55779
Date :
Date Event
10 November 2003Submitted
September 2004Published
Date Deposited: 05 Aug 2008
Last Modified: 16 Apr 2017 17:42
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/55779

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