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Fish as bioreactors: transgene expression of human coagulation factor VII in fish embryos

Hwang, Gyulin, Muller, Ferenc, Rahman, M. Aziz, Williams, Darren W., Murdock, Paul J., Pasi, K. John, Goldspink, Geoffrey, Farahmand, Hamid and Maclean, Norman (2004) Fish as bioreactors: transgene expression of human coagulation factor VII in fish embryos Marine Biotechnology, 6, (5), pp. 485-492. (doi:10.1007/s10126-004-3121-2).

Record type: Article

Abstract

A plasmid containing human coagulation factor VII (hFVII) complementary DNA regulated by a cytomegalovirus promoter was microinjected into fertilized eggs of zebrafish, African catfish, and tilapia. The active form of hFVll was detected in the fish embryos by various assays. This positive expression of human therapeutic protein in fish embryos demonstrates the possibility of exploitation of transgenic fish as bioreactors.

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More information

Submitted date: 10 November 2003
Published date: September 2004
Keywords: human coagulation factor VII, transgenic fish, bioreactor

Identifiers

Local EPrints ID: 55779
URI: http://eprints.soton.ac.uk/id/eprint/55779
ISSN: 1436-2228
PURE UUID: a8869c30-9141-4829-8072-3d451e44a641

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Date deposited: 05 Aug 2008
Last modified: 17 Jul 2017 14:32

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Contributors

Author: Gyulin Hwang
Author: Ferenc Muller
Author: M. Aziz Rahman
Author: Darren W. Williams
Author: Paul J. Murdock
Author: K. John Pasi
Author: Geoffrey Goldspink
Author: Hamid Farahmand
Author: Norman Maclean

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