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The role of desaturases in cold-induced lipid restructuring

The role of desaturases in cold-induced lipid restructuring
The role of desaturases in cold-induced lipid restructuring
All organisms respond to environmental challenge by adaptive responses, although, in many cases, the underlying molecular mechanisms are not understood. In the case of membranes, the physical structure of membrane phospholipids is conserved in the face of cold, rigidifying conditions by the elevated proportions of unsaturated fatty acids. We have observed a clear positional specificity in this substitution and head group preferences in carp liver membranes. We have also demonstrated changes in the activity of lipid desaturases that mediate the unsaturation response, caused by both transcriptional and post-translational mechanisms. Another hepatic isoform has recently been discovered with sensitivity, not to cooling, but to dietary variations. Finally, we are testing the importance of desaturase inductions in the inducible cold tolerance of the whole animal.
omeoviscous adaptation, membrane fluidity, temperature adaptation
0300-5127
1082-1086
Cossins, A.R.
6f688bd6-58cd-4793-a6db-dfece9098657
Murray, P.A.
dcdf7350-5dc8-4be8-be11-9f10c7c7305b
Gracey, A.Y.
192f2b86-3d3b-4eb7-8914-f15af81704dc
Logue, J.
f50943dc-2430-421d-ac1c-7cbf0819f0dd
Polley, S.
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Caddick, M.
1f56af58-8e7f-4110-a9c1-2c188ab0fef1
Brooks, S.
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Postle, T.
89734ccd-f868-4779-b744-58bdc8dba748
Maclean, N.
fc7272ea-27ce-4f19-bb5b-dbccb8c520a8
Cossins, A.R.
6f688bd6-58cd-4793-a6db-dfece9098657
Murray, P.A.
dcdf7350-5dc8-4be8-be11-9f10c7c7305b
Gracey, A.Y.
192f2b86-3d3b-4eb7-8914-f15af81704dc
Logue, J.
f50943dc-2430-421d-ac1c-7cbf0819f0dd
Polley, S.
4d5fb7db-f94b-4030-99be-a996951a6dc6
Caddick, M.
1f56af58-8e7f-4110-a9c1-2c188ab0fef1
Brooks, S.
4b0ecd34-a592-46b3-a21f-f83bdda46c7b
Postle, T.
89734ccd-f868-4779-b744-58bdc8dba748
Maclean, N.
fc7272ea-27ce-4f19-bb5b-dbccb8c520a8

Cossins, A.R., Murray, P.A., Gracey, A.Y., Logue, J., Polley, S., Caddick, M., Brooks, S., Postle, T. and Maclean, N. (2002) The role of desaturases in cold-induced lipid restructuring. Biochemical Society Transactions, 30, 1082-1086.

Record type: Article

Abstract

All organisms respond to environmental challenge by adaptive responses, although, in many cases, the underlying molecular mechanisms are not understood. In the case of membranes, the physical structure of membrane phospholipids is conserved in the face of cold, rigidifying conditions by the elevated proportions of unsaturated fatty acids. We have observed a clear positional specificity in this substitution and head group preferences in carp liver membranes. We have also demonstrated changes in the activity of lipid desaturases that mediate the unsaturation response, caused by both transcriptional and post-translational mechanisms. Another hepatic isoform has recently been discovered with sensitivity, not to cooling, but to dietary variations. Finally, we are testing the importance of desaturase inductions in the inducible cold tolerance of the whole animal.

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More information

Published date: November 2002
Keywords: omeoviscous adaptation, membrane fluidity, temperature adaptation

Identifiers

Local EPrints ID: 55811
URI: http://eprints.soton.ac.uk/id/eprint/55811
ISSN: 0300-5127
PURE UUID: 47f143a4-6a48-4e61-90be-ff839a263ed3

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Date deposited: 06 Aug 2008
Last modified: 13 Mar 2019 20:36

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