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The role of desaturases in cold-induced lipid restructuring

Cossins, A.R., Murray, P.A., Gracey, A.Y., Logue, J., Polley, S., Caddick, M., Brooks, S., Postle, T. and Maclean, N. (2002) The role of desaturases in cold-induced lipid restructuring Biochemical Society Transactions, 30, pp. 1082-1086.

Record type: Article


All organisms respond to environmental challenge by adaptive responses, although, in many cases, the underlying molecular mechanisms are not understood. In the case of membranes, the physical structure of membrane phospholipids is conserved in the face of cold, rigidifying conditions by the elevated proportions of unsaturated fatty acids. We have observed a clear positional specificity in this substitution and head group preferences in carp liver membranes. We have also demonstrated changes in the activity of lipid desaturases that mediate the unsaturation response, caused by both transcriptional and post-translational mechanisms. Another hepatic isoform has recently been discovered with sensitivity, not to cooling, but to dietary variations. Finally, we are testing the importance of desaturase inductions in the inducible cold tolerance of the whole animal.

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Published date: November 2002
Keywords: omeoviscous adaptation, membrane fluidity, temperature adaptation


Local EPrints ID: 55811
ISSN: 0300-5127
PURE UUID: 47f143a4-6a48-4e61-90be-ff839a263ed3

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Date deposited: 06 Aug 2008
Last modified: 17 Jul 2017 14:31

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Author: A.R. Cossins
Author: P.A. Murray
Author: A.Y. Gracey
Author: J. Logue
Author: S. Polley
Author: M. Caddick
Author: S. Brooks
Author: T. Postle
Author: N. Maclean

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