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Transgenic tilapia and the tilapia genome

Maclean, N., Rahman, M.A., Sohm, F., Hwang, G., Lyengar, A., Ayad, H., Smith, A. and Farahmand, H. (2002) Transgenic tilapia and the tilapia genome Gene, 295, (2), pp. 265-277. (doi:10.1016/S0378-1119(02)00735-7).

Record type: Article


The tilapia fish (Oreochromis niloticus) has an important place in the aquaculture of the developing world. It is also a very useful laboratory animal, and readily lends itself to the transgenic technology. Through the use of reporter genes, a range of potential gene promoters have been tested in tilapia, both through transient and stable expression of the reporter construct. Using the transgenic technology, growth enhanced lines of tilapia have been produced. These fish have no abnormalities and offer a considerable growth advantage for future exploitation. It is however crucial that transgenic fish, to be exploited in aquaculture, be sterile, and various methods of achieving sterility are considered. These include triploidy, gene knock out of crucial hormone encoding genes via homologous recombination, and knock down of the function of the same genes via ribozyme or antisense technologies.

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Submitted date: 10 August 2001
Published date: 7 August 2002
Keywords: transgenic fish, reporter gene, antisense, ribozyme, biofactory


Local EPrints ID: 55813
ISSN: 0378-1119
PURE UUID: dff385c7-7061-49ab-8f80-b0bcc11ffcab

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Date deposited: 06 Aug 2008
Last modified: 17 Jul 2017 14:31

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Author: N. Maclean
Author: M.A. Rahman
Author: F. Sohm
Author: G. Hwang
Author: A. Lyengar
Author: H. Ayad
Author: A. Smith
Author: H. Farahmand

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