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Society for Reproductive Biology Founders' Lecture 2003 - The making of an embryo: short-term goals and long-term implications

Society for Reproductive Biology Founders' Lecture 2003 - The making of an embryo: short-term goals and long-term implications
Society for Reproductive Biology Founders' Lecture 2003 - The making of an embryo: short-term goals and long-term implications
During early development, the eutherian mammalian embryo forms a blastocyst comprising an outer trophectoderm epithelium and enclosed inner cell mass (ICM). The short-term goal of blastocyst morphogenesis, including epithelial differentiation and segregation of the ICM, is mainly regulated autonomously and comprises a combination of temporally controlled gene expression, cell polarisation, differentiative cell divisions and cell–cell interactions. This aspect of blastocyst biogenesis is reviewed, focusing, in particular, on the maturation and role of cell adhesion systems. Early embryos are also sensitive to their environment, which can affect their developmental potential in diverse ways and may lead to long-term consequences relating to fetal or postnatal growth and physiology. Some current concepts of embryo–environment interactions, which may impact on future health, are also reviewed.
blastocyst, cell adhesion, compaction, environmental factors, fetal programming, inner cell mass, systolic blood pressure, tight junctions, trophectoderm
1031-3613
325-337
Fleming, T.P.
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Wilkins, A.
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Mears, A.
795dda89-bee7-4001-a37e-52d421ad5a34
Miller, D.J.
a230d4ba-cdd8-4e3b-8d96-3bc31863b7a8
Thomas, F.
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Ghassemifar, M.R.
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Fesenko, I.
b39e9c34-49df-40ee-992d-3e4a0af7e954
Sheth, B.
2ca6ed58-a992-47b7-b3a5-3c5df82aada7
Kwong, W.Y.
8c0db2b8-e2c0-46ea-b5d6-4ad632938062
Eckert, J.J.
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Fleming, T.P.
2abf761a-e5a1-4fa7-a2c8-12e32d5d4c03
Wilkins, A.
45d33137-731d-4b88-ac36-9af872690186
Mears, A.
795dda89-bee7-4001-a37e-52d421ad5a34
Miller, D.J.
a230d4ba-cdd8-4e3b-8d96-3bc31863b7a8
Thomas, F.
b6f33eb9-204c-4811-a788-cd7ddd221e32
Ghassemifar, M.R.
219dba14-d37d-4062-b687-bcdcc6889045
Fesenko, I.
b39e9c34-49df-40ee-992d-3e4a0af7e954
Sheth, B.
2ca6ed58-a992-47b7-b3a5-3c5df82aada7
Kwong, W.Y.
8c0db2b8-e2c0-46ea-b5d6-4ad632938062
Eckert, J.J.
1cbbbe6e-d005-444f-a4ad-57787c989517

Fleming, T.P., Wilkins, A., Mears, A., Miller, D.J., Thomas, F., Ghassemifar, M.R., Fesenko, I., Sheth, B., Kwong, W.Y. and Eckert, J.J. (2004) Society for Reproductive Biology Founders' Lecture 2003 - The making of an embryo: short-term goals and long-term implications. Reproduction, Fertility and Development, 16 (3), 325-337. (doi:10.1071/RD03070).

Record type: Article

Abstract

During early development, the eutherian mammalian embryo forms a blastocyst comprising an outer trophectoderm epithelium and enclosed inner cell mass (ICM). The short-term goal of blastocyst morphogenesis, including epithelial differentiation and segregation of the ICM, is mainly regulated autonomously and comprises a combination of temporally controlled gene expression, cell polarisation, differentiative cell divisions and cell–cell interactions. This aspect of blastocyst biogenesis is reviewed, focusing, in particular, on the maturation and role of cell adhesion systems. Early embryos are also sensitive to their environment, which can affect their developmental potential in diverse ways and may lead to long-term consequences relating to fetal or postnatal growth and physiology. Some current concepts of embryo–environment interactions, which may impact on future health, are also reviewed.

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More information

Published date: 11 February 2004
Keywords: blastocyst, cell adhesion, compaction, environmental factors, fetal programming, inner cell mass, systolic blood pressure, tight junctions, trophectoderm

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Local EPrints ID: 55864
URI: http://eprints.soton.ac.uk/id/eprint/55864
ISSN: 1031-3613
PURE UUID: 7526538b-3710-45f1-b485-99a5f70aec66

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Date deposited: 06 Aug 2008
Last modified: 08 Jan 2022 07:07

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Contributors

Author: T.P. Fleming
Author: A. Wilkins
Author: A. Mears
Author: D.J. Miller
Author: F. Thomas
Author: M.R. Ghassemifar
Author: I. Fesenko
Author: B. Sheth
Author: W.Y. Kwong
Author: J.J. Eckert

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