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Assembly of tight junctions during early vertebrate development

Assembly of tight junctions during early vertebrate development
Assembly of tight junctions during early vertebrate development
Tight junction formation during development is critical for embryonic patterning and organization. We consider mechanisms of junction biogenesis in cleaving mouse and Xenopus eggs. Junction assembly follows the establishment of cell polarity at 8-cell (mouse) or 2-cell (Xenopus) stages, characterized by sequential membrane delivery of constituents, coordinated by embryonic (mouse) or maternal (Xenopus) expression programmes. Cadherin adhesion is permissive for tight junction construction only in the mouse. Occludin post-translational modification and membrane delivery, mediated by delayed ZO-1 alpha+isoform expression in the mouse, provides a mechanism for completion of tight junction biogenesis and sealing, regulating the timing of blastocoel cavitation.
1084-9521
291-299
Fleming, T.P.
2abf761a-e5a1-4fa7-a2c8-12e32d5d4c03
Papenbrock, T.
ff77ce9c-910b-4e64-ac29-7a2cdcd52d48
Fesenko, I.
b39e9c34-49df-40ee-992d-3e4a0af7e954
Hausen, P.
5b29b870-342c-4467-ae39-b1f9d28596a9
Sheth, B.
2ca6ed58-a992-47b7-b3a5-3c5df82aada7
Fleming, T.P.
2abf761a-e5a1-4fa7-a2c8-12e32d5d4c03
Papenbrock, T.
ff77ce9c-910b-4e64-ac29-7a2cdcd52d48
Fesenko, I.
b39e9c34-49df-40ee-992d-3e4a0af7e954
Hausen, P.
5b29b870-342c-4467-ae39-b1f9d28596a9
Sheth, B.
2ca6ed58-a992-47b7-b3a5-3c5df82aada7

Fleming, T.P., Papenbrock, T., Fesenko, I., Hausen, P. and Sheth, B. (2000) Assembly of tight junctions during early vertebrate development. Seminars in Cell and Developmental Biology, 11 (4), 291-299. (doi:10.1006/scdb.2000.0179).

Record type: Article

Abstract

Tight junction formation during development is critical for embryonic patterning and organization. We consider mechanisms of junction biogenesis in cleaving mouse and Xenopus eggs. Junction assembly follows the establishment of cell polarity at 8-cell (mouse) or 2-cell (Xenopus) stages, characterized by sequential membrane delivery of constituents, coordinated by embryonic (mouse) or maternal (Xenopus) expression programmes. Cadherin adhesion is permissive for tight junction construction only in the mouse. Occludin post-translational modification and membrane delivery, mediated by delayed ZO-1 alpha+isoform expression in the mouse, provides a mechanism for completion of tight junction biogenesis and sealing, regulating the timing of blastocoel cavitation.

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Published date: August 2000

Identifiers

Local EPrints ID: 55867
URI: https://eprints.soton.ac.uk/id/eprint/55867
ISSN: 1084-9521
PURE UUID: 651bed7d-fa23-4de0-8115-880ca7c49529

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Date deposited: 06 Aug 2008
Last modified: 17 Jul 2017 14:31

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