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Inosine substitutions demonstrate that intramolecular DNA quadruplexes adopt different conformations in the presence of sodium and potassium

Risitano, A. and Fox, K.R. (2005) Inosine substitutions demonstrate that intramolecular DNA quadruplexes adopt different conformations in the presence of sodium and potassium Bioorganic & Medicinal Chemistry Letters, 15, (8), pp. 2047-2050. (doi:10.1016/j.bmcl.2005.02.050).

Record type: Article

Abstract

We have examined the stability of fluorescently-labelled oligonucleotides that are based on the human telomeric repeat [(GGGTTA)3GGG], in which one of the guanines in turn is substituted with inosine. We show that the relative stability of the substitutions is different in the presence of sodium and potassium. The data for potassium suggest a parallel arrangement of the strands, while the sodium form is mixed parallel and antiparallel.
Graphical abstract The relative stability of intramolecular quadruplexes containing inosine substitutions is different in sodium and potassium.

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More information

Published date: 15 April 2005
Keywords: G-quartet, quadruplex, fluorescence, molecular beacon, DNA melting, inosine

Identifiers

Local EPrints ID: 55887
URI: http://eprints.soton.ac.uk/id/eprint/55887
PURE UUID: 6a1cc652-04e3-4201-8c22-abbc06f351ac
ORCID for K.R. Fox: ORCID iD orcid.org/0000-0002-2925-7315

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Date deposited: 06 Aug 2008
Last modified: 17 Jul 2017 14:31

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Contributors

Author: A. Risitano
Author: K.R. Fox ORCID iD

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