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Inhibition of GABA uptake potentiates the effects of exogenous GABA on locust skeletal muscle

Inhibition of GABA uptake potentiates the effects of exogenous GABA on locust skeletal muscle
Inhibition of GABA uptake potentiates the effects of exogenous GABA on locust skeletal muscle
1. Insect skeletal muscle is relatively insensitive to applied GABA, responses are elicited only when relatively high concentrations of GABA are used (>10?6M).
2. Pretreatment of the muscle with the GABA uptake inhibitors nipecotic acid, ?-aminobutyric acid or ?-alanine increases the sensitivity of the muscle to GABA by as much as 1000-fold.
3. The evidence suggests the existence of a GABA uptake mechanism in the insect neuromuscular system which could reside in glial cells.
0742-8413
315-321
Shepherd, D.
11aa6858-d19c-4450-82ff-11dff9dcd9c4
Tyrer, N.M.
ca4e7ce6-b1e0-4630-81f8-a5c69a9a606f
Shepherd, D.
11aa6858-d19c-4450-82ff-11dff9dcd9c4
Tyrer, N.M.
ca4e7ce6-b1e0-4630-81f8-a5c69a9a606f

Shepherd, D. and Tyrer, N.M. (1985) Inhibition of GABA uptake potentiates the effects of exogenous GABA on locust skeletal muscle. Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 82 (2), 315-321. (doi:10.1016/0742-8413(85)90169-0).

Record type: Article

Abstract

1. Insect skeletal muscle is relatively insensitive to applied GABA, responses are elicited only when relatively high concentrations of GABA are used (>10?6M).
2. Pretreatment of the muscle with the GABA uptake inhibitors nipecotic acid, ?-aminobutyric acid or ?-alanine increases the sensitivity of the muscle to GABA by as much as 1000-fold.
3. The evidence suggests the existence of a GABA uptake mechanism in the insect neuromuscular system which could reside in glial cells.

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Published date: 1985
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Identifiers

Local EPrints ID: 55893
URI: http://eprints.soton.ac.uk/id/eprint/55893
DOI: doi:10.1016/0742-8413(85)90169-0
ISSN: 0742-8413
PURE UUID: f02a2b5c-ac19-4e95-8d45-cd16c029d7e4
ORCID for D. Shepherd: ORCID iD orcid.org/0000-0002-6961-7880

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Date deposited: 22 Aug 2008
Last modified: 06 Aug 2024 01:52

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Author: D. Shepherd ORCID iD
Author: N.M. Tyrer

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