Inhibition of GABA uptake potentiates the effects of exogenous GABA on locust skeletal muscle
Inhibition of GABA uptake potentiates the effects of exogenous GABA on locust skeletal muscle
1. Insect skeletal muscle is relatively insensitive to applied GABA, responses are elicited only when relatively high concentrations of GABA are used (>10?6M).
2. Pretreatment of the muscle with the GABA uptake inhibitors nipecotic acid, ?-aminobutyric acid or ?-alanine increases the sensitivity of the muscle to GABA by as much as 1000-fold.
3. The evidence suggests the existence of a GABA uptake mechanism in the insect neuromuscular system which could reside in glial cells.
315-321
Shepherd, D.
11aa6858-d19c-4450-82ff-11dff9dcd9c4
Tyrer, N.M.
ca4e7ce6-b1e0-4630-81f8-a5c69a9a606f
1985
Shepherd, D.
11aa6858-d19c-4450-82ff-11dff9dcd9c4
Tyrer, N.M.
ca4e7ce6-b1e0-4630-81f8-a5c69a9a606f
Shepherd, D. and Tyrer, N.M.
(1985)
Inhibition of GABA uptake potentiates the effects of exogenous GABA on locust skeletal muscle.
Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 82 (2), .
(doi:10.1016/0742-8413(85)90169-0).
Abstract
1. Insect skeletal muscle is relatively insensitive to applied GABA, responses are elicited only when relatively high concentrations of GABA are used (>10?6M).
2. Pretreatment of the muscle with the GABA uptake inhibitors nipecotic acid, ?-aminobutyric acid or ?-alanine increases the sensitivity of the muscle to GABA by as much as 1000-fold.
3. The evidence suggests the existence of a GABA uptake mechanism in the insect neuromuscular system which could reside in glial cells.
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Published date: 1985
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Local EPrints ID: 55893
URI: http://eprints.soton.ac.uk/id/eprint/55893
ISSN: 0742-8413
PURE UUID: f02a2b5c-ac19-4e95-8d45-cd16c029d7e4
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Date deposited: 22 Aug 2008
Last modified: 15 Mar 2024 10:58
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Author:
N.M. Tyrer
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