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Inhibition of GABA uptake potentiates the effects of exogenous GABA on locust skeletal muscle

Record type: Article

1. Insect skeletal muscle is relatively insensitive to applied GABA, responses are elicited only when relatively high concentrations of GABA are used (>10?6M).
2. Pretreatment of the muscle with the GABA uptake inhibitors nipecotic acid, ?-aminobutyric acid or ?-alanine increases the sensitivity of the muscle to GABA by as much as 1000-fold.
3. The evidence suggests the existence of a GABA uptake mechanism in the insect neuromuscular system which could reside in glial cells.

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Citation

Shepherd, D. and Tyrer, N.M. (1985) Inhibition of GABA uptake potentiates the effects of exogenous GABA on locust skeletal muscle Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 82, (2), pp. 315-321. (doi:10.1016/0742-8413(85)90169-0).

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Published date: 1985

Identifiers

Local EPrints ID: 55893
URI: http://eprints.soton.ac.uk/id/eprint/55893
ISSN: 0742-8413
PURE UUID: f02a2b5c-ac19-4e95-8d45-cd16c029d7e4

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Date deposited: 22 Aug 2008
Last modified: 17 Jul 2017 14:31

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Author: D. Shepherd
Author: N.M. Tyrer

University divisions

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