Shepherd, D. and Tyrer, N.M.
Inhibition of GABA uptake potentiates the effects of exogenous GABA on locust skeletal muscle
Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 82, (2), . (doi:10.1016/0742-8413(85)90169-0).
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1. Insect skeletal muscle is relatively insensitive to applied GABA, responses are elicited only when relatively high concentrations of GABA are used (>10?6M).
2. Pretreatment of the muscle with the GABA uptake inhibitors nipecotic acid, ?-aminobutyric acid or ?-alanine increases the sensitivity of the muscle to GABA by as much as 1000-fold.
3. The evidence suggests the existence of a GABA uptake mechanism in the insect neuromuscular system which could reside in glial cells.
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