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Alpha-synuclein overexpression promotes aggregation of mutant huntingtin

Alpha-synuclein overexpression promotes aggregation of mutant huntingtin
Alpha-synuclein overexpression promotes aggregation of mutant huntingtin
Protein aggregates are a neuropathological feature of Huntington's disease and Parkinson's disease. Mutant huntingtin exon 1 with 72 CAG repeats fused to enhanced green fluorescent protein (EGFP) forms hyperfluorescent inclusions in PC12 cells. Inclusion formation is enhanced in cells co-transfected with EGFP-huntingtin-(CAG)(72) and alpha-synuclein, a major component of Parkinson's disease aggregates. However, alpha-synuclein does not form aggregates by itself, nor does it appear in huntingtin inclusions in vitro.
1470-8728
577-581
Furlong, R.A.
68208c6e-6bdb-4de6-bf2a-1e96b84fe55e
Narain, Y.
250fa42a-e4c0-4b7d-8593-4c89236acd73
Rankin, J.
f46fdd1f-6006-4a21-ace2-b4d8d8c85c20
Wyttenbach, A.
69846a0f-fb60-4a28-84eb-ed865a5e31fa
Rubinsztein, D.C.
7bc49386-aa67-4658-a966-0d952e6fd731
Furlong, R.A.
68208c6e-6bdb-4de6-bf2a-1e96b84fe55e
Narain, Y.
250fa42a-e4c0-4b7d-8593-4c89236acd73
Rankin, J.
f46fdd1f-6006-4a21-ace2-b4d8d8c85c20
Wyttenbach, A.
69846a0f-fb60-4a28-84eb-ed865a5e31fa
Rubinsztein, D.C.
7bc49386-aa67-4658-a966-0d952e6fd731

Furlong, R.A., Narain, Y., Rankin, J., Wyttenbach, A. and Rubinsztein, D.C. (2000) Alpha-synuclein overexpression promotes aggregation of mutant huntingtin. Biochemical Journal, 346 (3), 577-581.

Record type: Article

Abstract

Protein aggregates are a neuropathological feature of Huntington's disease and Parkinson's disease. Mutant huntingtin exon 1 with 72 CAG repeats fused to enhanced green fluorescent protein (EGFP) forms hyperfluorescent inclusions in PC12 cells. Inclusion formation is enhanced in cells co-transfected with EGFP-huntingtin-(CAG)(72) and alpha-synuclein, a major component of Parkinson's disease aggregates. However, alpha-synuclein does not form aggregates by itself, nor does it appear in huntingtin inclusions in vitro.

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Published date: 15 March 2000

Identifiers

Local EPrints ID: 55906
URI: https://eprints.soton.ac.uk/id/eprint/55906
ISSN: 1470-8728
PURE UUID: 2fa3f772-e931-45f0-9811-b6ad600a6f39

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Date deposited: 06 Aug 2008
Last modified: 17 Jul 2017 14:31

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Contributors

Author: R.A. Furlong
Author: Y. Narain
Author: J. Rankin
Author: A. Wyttenbach
Author: D.C. Rubinsztein

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