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Physiological and pharmacological studies on nematodes

Physiological and pharmacological studies on nematodes
Physiological and pharmacological studies on nematodes
Classical transmitters and neuroactive peptides act as transmitters or modulators within the central and peripheral nervous systems of nematodes, for example Ascaris suum and Caenorhabditis elegans. Acetylcholine (ACh) and gamma-aminobutyric acid (GABA) are respectively the excitatory and inhibitory transmitters onto somatic body wall muscle while 5-hydroxytrypamine (5-HT) is the excitatory transmitter onto pharyngeal muscle. 5-HT also reduces ACh-induced contractions of somatic muscle and this action of 5-HT is mediated through activation of adenylate cyclase while that on pharyngeal muscle is mediated through inositol phosphate activation. Glutamate, dopamine and octopamine also have transmitter roles in nematodes. Neuroactive peptides of the RFamide family can excite somatic muscle, for example, AF-1 (KNEFIRFamide), AF-2 (KHEYLRFamide), AF-3 (AVPGVLRFamide) and AF-4 (GDVPGVLRFamide) or inhibit and relax this muscle, for example, PF-1 (SDPNFLRFamide), PF-2 (SADPNFLRFamide) and PF-4 (KPNlRFamide). In addition PF-3 (AF-8) (KSAYMRFamide) has a biphasic action on pharyngeal muscle, excitation followed by inhibition while AF-1 only inhibits this muscle. The peptide effects can be either pre- or postsynaptic or both and are likely to be mediated through second messenger systems. In addition these peptides modulate the action of classical transmitters, particularly ACh.
0236-5383
379-394
Walker, R.J.
f4a81273-566d-455c-95fa-42162d468ff8
Franks, C.J.
d6723765-2749-4a19-af62-c97161f4c18e
Pemberton, D.
9cce4d78-2dd1-4e0a-aeae-26a08a4b3dc6
Rogers, C.
bf8572a5-8137-46f4-9e99-0fbecda54451
Holden-Dye, L.
8032bf60-5db6-40cb-b71c-ddda9d212c8e
Walker, R.J.
f4a81273-566d-455c-95fa-42162d468ff8
Franks, C.J.
d6723765-2749-4a19-af62-c97161f4c18e
Pemberton, D.
9cce4d78-2dd1-4e0a-aeae-26a08a4b3dc6
Rogers, C.
bf8572a5-8137-46f4-9e99-0fbecda54451
Holden-Dye, L.
8032bf60-5db6-40cb-b71c-ddda9d212c8e

Walker, R.J., Franks, C.J., Pemberton, D., Rogers, C. and Holden-Dye, L. (2000) Physiological and pharmacological studies on nematodes. Acta Biologica Hungarica, 51 (2-4), 379-394.

Record type: Article

Abstract

Classical transmitters and neuroactive peptides act as transmitters or modulators within the central and peripheral nervous systems of nematodes, for example Ascaris suum and Caenorhabditis elegans. Acetylcholine (ACh) and gamma-aminobutyric acid (GABA) are respectively the excitatory and inhibitory transmitters onto somatic body wall muscle while 5-hydroxytrypamine (5-HT) is the excitatory transmitter onto pharyngeal muscle. 5-HT also reduces ACh-induced contractions of somatic muscle and this action of 5-HT is mediated through activation of adenylate cyclase while that on pharyngeal muscle is mediated through inositol phosphate activation. Glutamate, dopamine and octopamine also have transmitter roles in nematodes. Neuroactive peptides of the RFamide family can excite somatic muscle, for example, AF-1 (KNEFIRFamide), AF-2 (KHEYLRFamide), AF-3 (AVPGVLRFamide) and AF-4 (GDVPGVLRFamide) or inhibit and relax this muscle, for example, PF-1 (SDPNFLRFamide), PF-2 (SADPNFLRFamide) and PF-4 (KPNlRFamide). In addition PF-3 (AF-8) (KSAYMRFamide) has a biphasic action on pharyngeal muscle, excitation followed by inhibition while AF-1 only inhibits this muscle. The peptide effects can be either pre- or postsynaptic or both and are likely to be mediated through second messenger systems. In addition these peptides modulate the action of classical transmitters, particularly ACh.

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Published date: 2000

Identifiers

Local EPrints ID: 55907
URI: https://eprints.soton.ac.uk/id/eprint/55907
ISSN: 0236-5383
PURE UUID: 85d38bdf-1737-4dfb-967c-cfb70363e031

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Date deposited: 06 Aug 2008
Last modified: 17 Jul 2017 14:31

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Contributors

Author: R.J. Walker
Author: C.J. Franks
Author: D. Pemberton
Author: C. Rogers
Author: L. Holden-Dye

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