History, biological mechanisms of action and clinical indications of intravenous immunoglobulin (IVIG) preparations
History, biological mechanisms of action and clinical indications of intravenous immunoglobulin (IVIG) preparations
Intravenous immunoglobulin (IVIG) preparations were initially introduced as replacement therapy in primary antibody deficiency disorders and, as time passed by, have been found beneficial in patients with autoimmune disorders and systemic inflammatory disease as well. In spite of its widespread use, the precise mechanism of action of IVIG is still largely unknown. Different mechanisms have been proposed, such as Fc[gamma] receptor blockade, inhibition of complement deposition, neutralization of superantigens, neutralization of cytokines and manipulation of the idiotypic network. Although well tolerated by most patients, IVIG may induce side effects in some patients. The fact that most of the commercially available IVIG preparation are free of complement-activating activity suggests that other effector mechanisms are involved. In this review, different biological mechanisms of action of IVIG as well as the causes of side effects are discussed.
91-100
Teeling, Jessica.L.
fcde1c8e-e5f8-4747-9f3a-6bdb5cd87d0a
Bleeker, Wim.K.
11ce7c46-56b6-4e31-95fc-bbc02d96dd07
Hack, C.Erik
f2a19948-e2ab-4747-962f-e6d46921a243
1 July 2002
Teeling, Jessica.L.
fcde1c8e-e5f8-4747-9f3a-6bdb5cd87d0a
Bleeker, Wim.K.
11ce7c46-56b6-4e31-95fc-bbc02d96dd07
Hack, C.Erik
f2a19948-e2ab-4747-962f-e6d46921a243
Teeling, Jessica.L., Bleeker, Wim.K. and Hack, C.Erik
(2002)
History, biological mechanisms of action and clinical indications of intravenous immunoglobulin (IVIG) preparations.
Reviews in Medical Microbiology, 13 (3), .
Abstract
Intravenous immunoglobulin (IVIG) preparations were initially introduced as replacement therapy in primary antibody deficiency disorders and, as time passed by, have been found beneficial in patients with autoimmune disorders and systemic inflammatory disease as well. In spite of its widespread use, the precise mechanism of action of IVIG is still largely unknown. Different mechanisms have been proposed, such as Fc[gamma] receptor blockade, inhibition of complement deposition, neutralization of superantigens, neutralization of cytokines and manipulation of the idiotypic network. Although well tolerated by most patients, IVIG may induce side effects in some patients. The fact that most of the commercially available IVIG preparation are free of complement-activating activity suggests that other effector mechanisms are involved. In this review, different biological mechanisms of action of IVIG as well as the causes of side effects are discussed.
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Published date: 1 July 2002
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Local EPrints ID: 55909
URI: http://eprints.soton.ac.uk/id/eprint/55909
ISSN: 0954-139X
PURE UUID: 491d65bd-d1e4-46ee-942d-6f14e162785a
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Date deposited: 06 Aug 2008
Last modified: 09 Jan 2022 03:17
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Author:
Wim.K. Bleeker
Author:
C.Erik Hack
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