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Inactivation of calcium channels

Chad, John (1989) Inactivation of calcium channels Comparative Biochemistry and Physiology Part A: Physiology, 93, (1), pp. 95-105. (doi:10.1016/0300-9629(89)90196-5).

Record type: Article


Rapid progress in our understanding of the properties and functions of voltage-gated calcium channels has produced the need for an update to our previous review of calcium inactivation. The major elements of change included in this review are:
1. 1. The existence of multiple forms of voltage-sensitive Ca+ channels, with distinctive single channel properties, thus necessitating a reappraisal of properties deduced from macroscopic current recordings, particularly of the processes of activation and inactivation.
2. 2. The differences in biochemical properties between channel types are reflected in their differences in divalent selectivity, their requirement for metabolic maintenance and their mechanism of inactivation. These properties appear to divide the channels into two categories which may relate to their molecular structures. Further subgroupings, based upon the voltage thresholds, have also been observed.
3. 3. Molecular properties of one class of channels have been elucidated, which correlate with the observed biochemistry of channel modulation and inactivation.
4. 4. An enzymatic process underlying the mechanism of Ca2+-dependent inactivation has been elucidated and may serve as a model for other modulatory systems.
The interweaving of the properties of these Ca2+ channels, with their spatial distributions and their influence upon other channel types, acts to transduce and integrate information within cells.

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Published date: 1989


Local EPrints ID: 55939
ISSN: 0300-9629
PURE UUID: 9eecea3b-5c50-450d-acf7-00e11555481d
ORCID for John Chad: ORCID iD

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Date deposited: 26 Aug 2008
Last modified: 17 Jul 2017 14:31

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