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Acute intermittent porphyria in Sweden. Molecular, functional and clinical consequences of some new mutations found in the porphobilinogen deaminase gene

Record type: Article

Acute intermittent porphyria (AIP) is an autosomal dominant disorder caused by a partial deficit of porphobilinogen deaminase (PBGD), the third of eight enzymes in the haem biosynthetic pathway. The overt disease is characterized by neuropsychiatric symptoms that are often triggered by exogenous factors such as certain drugs, stress, and alcohol. The aim of this work has been to identify the underlying genetic defect in each AIP-affected family in order to provide early counselling to assist in the avoidance of precipitating factors. The prevalence of AIP in Sweden is in the order of 1:10 000. The major mutation in Sweden, W198X, is due to a founder effect in the northern part of the country. This mutation, together with a further 11 mutations, have been reported previously. The present communication encompasses the great majority of AIP kindreds in Sweden and includes a further 27 mutations within the PBGD gene. This includes 14 completely new mutations, as well as 11 known mutations detected for the first time in Sweden. The majority of the mutations are located in exons 10 and 12 with fewer in exon 7. The clinical and biochemical outcomes in some patients are described. We also use the three-dimensional structure of the porphobilinogen deaminase enzyme to predict the possible molecular and functional consequences of the new Swedish missense and nonsense mutations.

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Citation

Floderus, Y., Shoolingin-Jordan, P.M. and Harper, P. (2002) Acute intermittent porphyria in Sweden. Molecular, functional and clinical consequences of some new mutations found in the porphobilinogen deaminase gene Clinical Genetics, 62, (4), pp. 288-297. (doi:10.1034/j.1399-0004.2002.620406.x).

More information

Published date: 1 October 2002
Keywords: acute intermittent porphyria, mutation, porphobilinogen deaminase, structure function relationships

Identifiers

Local EPrints ID: 55944
URI: http://eprints.soton.ac.uk/id/eprint/55944
ISSN: 0009-9163
PURE UUID: 30c8de92-4a76-4a51-9b43-ecaba5f89ccd

Catalogue record

Date deposited: 07 Aug 2008
Last modified: 17 Jul 2017 14:31

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Contributors

Author: Y. Floderus
Author: P. Harper

University divisions


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