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Cleavage of translation initiation factor 4AI (eIF4AI) but not eIF4AII by foot-and-mouth disease virus 3C protease: identification of the eIF4AI cleavage site

Lin, Wei, Ross-Smith, Natalie, Proud, Christopher G., Belsham, Graham J. and Avila, Jesus (ed.) (2001) Cleavage of translation initiation factor 4AI (eIF4AI) but not eIF4AII by foot-and-mouth disease virus 3C protease: identification of the eIF4AI cleavage site Febs Letters, 507, (1), pp. 1-5.

Record type: Article

Abstract

The translation initiation factor eIF4A is cleaved within mammalian cells infected by foot-and-mouth disease virus (FMDV). The FMDV 3C protease cleaves eIF4AI (between residues E143 and V144), but not the closely related eIF4AII. Modification of eIF4AI, to produce a sequence identical to eIF4AII around the cleavage site, blocked proteolysis. Alignment of mammalian eIF4AI onto the three-dimensional structure of yeast eIF4A located the scissile bond within an exposed, flexible portion of the molecule. The N- and C-terminal cleavage products of eIF4AI generated by FMDV 3C dissociate. Cleavage of eIF4AI by FMDV 3C is thus expected to inactivate it.

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More information

Published date: 19 October 2001
Keywords: picornavirus, translation initiation factor eIF4A, protein synthesis, 3C protease, foot-and-mouth disease virus

Identifiers

Local EPrints ID: 55964
URI: http://eprints.soton.ac.uk/id/eprint/55964
ISSN: 0014-5793
PURE UUID: eb6e47f2-bca7-4bf6-9930-a8ccb2588658

Catalogue record

Date deposited: 07 Aug 2008
Last modified: 17 Jul 2017 14:31

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Contributors

Author: Wei Lin
Author: Natalie Ross-Smith
Author: Christopher G. Proud
Author: Graham J. Belsham
Author: Jesus (ed.) Avila

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