Junctional complexes in the early mammalian embryo
Junctional complexes in the early mammalian embryo
Preimplantation embryos generate intercellular junctions during differentiation of the trophectoderm epithelium and the formation of the blastocyst. These membrane complexes comprise gap junctions, adherens junctions, tight junctions, and desmosomes, each performing fundamental roles in cellular communication, adhesion, and differentiation. The mouse embryo has been used as a model for the biogenesis of cell junctions. Their construction is achieved by temporally regulated gene expression programs. Mechanisms of junction membrane assembly include the timing of transcription, translation, and posttranslational modifications of specific junctional proteins. Human embryos exhibit similar expression programs, and defects in these programs may contribute to reduced embryo viability.
junctions, blastocyst
185-193
Fleming, T.P.
2abf761a-e5a1-4fa7-a2c8-12e32d5d4c03
Ghassemifar, M.R.
219dba14-d37d-4062-b687-bcdcc6889045
Sheth, B.
2ca6ed58-a992-47b7-b3a5-3c5df82aada7
1 January 2000
Fleming, T.P.
2abf761a-e5a1-4fa7-a2c8-12e32d5d4c03
Ghassemifar, M.R.
219dba14-d37d-4062-b687-bcdcc6889045
Sheth, B.
2ca6ed58-a992-47b7-b3a5-3c5df82aada7
Fleming, T.P., Ghassemifar, M.R. and Sheth, B.
(2000)
Junctional complexes in the early mammalian embryo.
Seminars in Reproductive Medicine, 18 (2), .
(doi:10.1055/s-2000-12557).
Abstract
Preimplantation embryos generate intercellular junctions during differentiation of the trophectoderm epithelium and the formation of the blastocyst. These membrane complexes comprise gap junctions, adherens junctions, tight junctions, and desmosomes, each performing fundamental roles in cellular communication, adhesion, and differentiation. The mouse embryo has been used as a model for the biogenesis of cell junctions. Their construction is achieved by temporally regulated gene expression programs. Mechanisms of junction membrane assembly include the timing of transcription, translation, and posttranslational modifications of specific junctional proteins. Human embryos exhibit similar expression programs, and defects in these programs may contribute to reduced embryo viability.
This record has no associated files available for download.
More information
Published date: 1 January 2000
Keywords:
junctions, blastocyst
Identifiers
Local EPrints ID: 56005
URI: http://eprints.soton.ac.uk/id/eprint/56005
PURE UUID: eae382ae-dd2f-4677-89bf-8c3698584158
Catalogue record
Date deposited: 21 Aug 2008
Last modified: 15 Mar 2024 10:59
Export record
Altmetrics
Contributors
Author:
M.R. Ghassemifar
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics