Junctional complexes in the early mammalian embryo

Fleming, T.P., Ghassemifar, M.R. and Sheth, B. (2000) Junctional complexes in the early mammalian embryo Seminars in Reproductive Medicine, 18, (2), pp. 185-193. (doi:10.1055/s-2000-12557).


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Preimplantation embryos generate intercellular junctions during differentiation of the trophectoderm epithelium and the formation of the blastocyst. These membrane complexes comprise gap junctions, adherens junctions, tight junctions, and desmosomes, each performing fundamental roles in cellular communication, adhesion, and differentiation. The mouse embryo has been used as a model for the biogenesis of cell junctions. Their construction is achieved by temporally regulated gene expression programs. Mechanisms of junction membrane assembly include the timing of transcription, translation, and posttranslational modifications of specific junctional proteins. Human embryos exhibit similar expression programs, and defects in these programs may contribute to reduced embryo viability.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1055/s-2000-12557
Keywords: junctions, blastocyst

ePrint ID: 56005
Date :
Date Event
1 January 2000Published
Date Deposited: 21 Aug 2008
Last Modified: 16 Apr 2017 17:42
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/56005

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