The University of Southampton
University of Southampton Institutional Repository

Directing quadruplex-stabilizing drugs to the telomere: Synthesis and properties of acridine - Oligonucleotide conjugates

Record type: Article

Conjugates containing quadruplex-stabilizing acridines linked to oligonucleotides that are complementary to the G-rich human telomere sequence were synthesized. Acylation of 3,6-diaminoacridine followed by two Michael reactions provided derivatives suitable for conjugation, which were coupled to resin-linked amine-modified oligonucleotides by activating the carboxyl group with pentafluorophenyl 4-nitrobenzenesulfonate. After deprotection with aqueous ammonia at room temperature, conjugates incorporating different acridines, linkers, and oligonucleotide sequences were obtained. These were tested for their ability to stabilize intramolecular DNA quadruplexes that are based on the human telomeric repeat sequence (GGGTTA)n.

Full text not available from this repository.

Citation

Casals, J., Debethune, L., Alvarez, K., Risitano, A., Fox, K.R., Grandas, A. and Pedroso, E. (2006) Directing quadruplex-stabilizing drugs to the telomere: Synthesis and properties of acridine - Oligonucleotide conjugates Bioconjugate Chemistry, 17, pp. 1351-1359. (doi:10.1021/bc060194t).

More information

Published date: 2 September 2006

Identifiers

Local EPrints ID: 56009
URI: http://eprints.soton.ac.uk/id/eprint/56009
ISSN: 1043-1802
PURE UUID: 85b82e31-3a1e-49f8-8ab4-2b79aa51397a
ORCID for K.R. Fox: ORCID iD orcid.org/0000-0002-2925-7315

Catalogue record

Date deposited: 07 Aug 2008
Last modified: 17 Jul 2017 14:31

Export record

Altmetrics

Contributors

Author: J. Casals
Author: L. Debethune
Author: K. Alvarez
Author: A. Risitano
Author: K.R. Fox ORCID iD
Author: A. Grandas
Author: E. Pedroso

University divisions


Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×