Blood-derived dendritic cells in an acute brain injury
Blood-derived dendritic cells in an acute brain injury
Dendritic cells (DC), while absent from the normal CNS parenchyma, have been demonstrated in delayed type hypersensitivity (DTH), experimental allergic encephalomyelitis (EAE), and some MS lesions. We demonstrate that an acute excitotoxic lesion results in DC recruitment to the brain, with maximal cells between days 3 and 5. Clodronate liposome-mediated depletion of cerebral perivascular macrophages does not prevent recruitment of DC; however, a lesion in a whole-body irradiated animal does not show evidence of DC recruitment. We conclude that DC are recruited to an excitotoxic lesion from a blood-derived cell population. This may have implications for neuropathologies involving DC recruitment.
dendritic cell, brain, perivascular macrophage, liposome, multiple sclerosis
167-172
Newman, Tracey A.
322290cb-2e9c-445d-a047-00b1bea39a25
Galea, Ian
66209a2f-f7e6-4d63-afe4-e9299f156f0b
van Rooijen, Nico
a9f3fc94-192d-4e2d-b662-765bd778bc55
Perry, V. Hugh
8f29d36a-8e1f-4082-8700-09483bbaeae4
September 2005
Newman, Tracey A.
322290cb-2e9c-445d-a047-00b1bea39a25
Galea, Ian
66209a2f-f7e6-4d63-afe4-e9299f156f0b
van Rooijen, Nico
a9f3fc94-192d-4e2d-b662-765bd778bc55
Perry, V. Hugh
8f29d36a-8e1f-4082-8700-09483bbaeae4
Newman, Tracey A., Galea, Ian, van Rooijen, Nico and Perry, V. Hugh
(2005)
Blood-derived dendritic cells in an acute brain injury.
Journal of Neuroimmunology, 166 (1-2), .
(doi:10.1016/j.jneuroim.2005.04.026).
Abstract
Dendritic cells (DC), while absent from the normal CNS parenchyma, have been demonstrated in delayed type hypersensitivity (DTH), experimental allergic encephalomyelitis (EAE), and some MS lesions. We demonstrate that an acute excitotoxic lesion results in DC recruitment to the brain, with maximal cells between days 3 and 5. Clodronate liposome-mediated depletion of cerebral perivascular macrophages does not prevent recruitment of DC; however, a lesion in a whole-body irradiated animal does not show evidence of DC recruitment. We conclude that DC are recruited to an excitotoxic lesion from a blood-derived cell population. This may have implications for neuropathologies involving DC recruitment.
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Published date: September 2005
Keywords:
dendritic cell, brain, perivascular macrophage, liposome, multiple sclerosis
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Local EPrints ID: 56019
URI: http://eprints.soton.ac.uk/id/eprint/56019
ISSN: 0165-5728
PURE UUID: b219bd3f-9cc2-4b1b-bfe0-988cc263a30c
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Date deposited: 08 Aug 2008
Last modified: 16 Mar 2024 03:33
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Author:
Nico van Rooijen
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