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Blood-derived dendritic cells in an acute brain injury

Blood-derived dendritic cells in an acute brain injury
Blood-derived dendritic cells in an acute brain injury
Dendritic cells (DC), while absent from the normal CNS parenchyma, have been demonstrated in delayed type hypersensitivity (DTH), experimental allergic encephalomyelitis (EAE), and some MS lesions. We demonstrate that an acute excitotoxic lesion results in DC recruitment to the brain, with maximal cells between days 3 and 5. Clodronate liposome-mediated depletion of cerebral perivascular macrophages does not prevent recruitment of DC; however, a lesion in a whole-body irradiated animal does not show evidence of DC recruitment. We conclude that DC are recruited to an excitotoxic lesion from a blood-derived cell population. This may have implications for neuropathologies involving DC recruitment.
dendritic cell, brain, perivascular macrophage, liposome, multiple sclerosis
0165-5728
167-172
Newman, Tracey A.
322290cb-2e9c-445d-a047-00b1bea39a25
Galea, Ian
66209a2f-f7e6-4d63-afe4-e9299f156f0b
van Rooijen, Nico
a9f3fc94-192d-4e2d-b662-765bd778bc55
Perry, V. Hugh
8f29d36a-8e1f-4082-8700-09483bbaeae4
Newman, Tracey A.
322290cb-2e9c-445d-a047-00b1bea39a25
Galea, Ian
66209a2f-f7e6-4d63-afe4-e9299f156f0b
van Rooijen, Nico
a9f3fc94-192d-4e2d-b662-765bd778bc55
Perry, V. Hugh
8f29d36a-8e1f-4082-8700-09483bbaeae4

Newman, Tracey A., Galea, Ian, van Rooijen, Nico and Perry, V. Hugh (2005) Blood-derived dendritic cells in an acute brain injury. Journal of Neuroimmunology, 166 (1-2), 167-172. (doi:10.1016/j.jneuroim.2005.04.026).

Record type: Article

Abstract

Dendritic cells (DC), while absent from the normal CNS parenchyma, have been demonstrated in delayed type hypersensitivity (DTH), experimental allergic encephalomyelitis (EAE), and some MS lesions. We demonstrate that an acute excitotoxic lesion results in DC recruitment to the brain, with maximal cells between days 3 and 5. Clodronate liposome-mediated depletion of cerebral perivascular macrophages does not prevent recruitment of DC; however, a lesion in a whole-body irradiated animal does not show evidence of DC recruitment. We conclude that DC are recruited to an excitotoxic lesion from a blood-derived cell population. This may have implications for neuropathologies involving DC recruitment.

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Published date: September 2005
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Keywords: dendritic cell, brain, perivascular macrophage, liposome, multiple sclerosis
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Identifiers

Local EPrints ID: 56019
URI: https://eprints.soton.ac.uk/id/eprint/56019
DOI: doi:10.1016/j.jneuroim.2005.04.026
ISSN: 0165-5728
PURE UUID: b219bd3f-9cc2-4b1b-bfe0-988cc263a30c
ORCID for Tracey A. Newman: ORCID iD orcid.org/0000-0002-3727-9258
ORCID for Ian Galea: ORCID iD orcid.org/0000-0002-1268-5102

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Date deposited: 08 Aug 2008
Last modified: 20 Jul 2019 01:17

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Contributors

Author: Tracey A. Newman ORCID iD
Author: Ian Galea ORCID iD
Author: Nico van Rooijen
Author: V. Hugh Perry

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