The University of Southampton
University of Southampton Institutional Repository

Neural repair and glial proliferation: parallels with gliogenesis in insects

Neural repair and glial proliferation: parallels with gliogenesis in insects
Neural repair and glial proliferation: parallels with gliogenesis in insects
There is a growing recognition, stemming from work with both vertebrates and invertebrates, that the capacity for neuronal regeneration is critically dependent on the local microenvironment. That environment is largely created by the non-neuronal elements of the nervous system, the neuroglia. Therefore an understanding of how glial cells respond to injury is crucial to understanding neuronal regeneration. Here we examine the process of repair in a relatively simple nervous system, that of the insect, in which it is possible to define precisely the cellular events of the repair process. This repair is rapid and well organised; it involves the recruitment of blood cells, the division of endogenous glial elements and, possibly, migration from pre-existing glial pools in adjacent ganglia. There are clear parallels between the events of repair and those of normal glial development. It seems likely that the ability of the insect central nervous system to repair resides in the retention of developmental capacities throughout its life and that damage results in the activation of this potential.
0265-9247
65-72
Smith, Peter J.S.
9e0aa945-95f1-40fe-aa26-ab5f3a3a193f
Shepherd, David
11aa6858-d19c-4450-82ff-11dff9dcd9c4
Edwards, John S.
af7bbd05-4fdd-490b-a3df-fc12d3636efd
Smith, Peter J.S.
9e0aa945-95f1-40fe-aa26-ab5f3a3a193f
Shepherd, David
11aa6858-d19c-4450-82ff-11dff9dcd9c4
Edwards, John S.
af7bbd05-4fdd-490b-a3df-fc12d3636efd

Smith, Peter J.S., Shepherd, David and Edwards, John S. (1991) Neural repair and glial proliferation: parallels with gliogenesis in insects. BioEssays, 13 (2), 65-72. (doi:10.1002/bies.950130204). (PMID:2029267)

Record type: Article

Abstract

There is a growing recognition, stemming from work with both vertebrates and invertebrates, that the capacity for neuronal regeneration is critically dependent on the local microenvironment. That environment is largely created by the non-neuronal elements of the nervous system, the neuroglia. Therefore an understanding of how glial cells respond to injury is crucial to understanding neuronal regeneration. Here we examine the process of repair in a relatively simple nervous system, that of the insect, in which it is possible to define precisely the cellular events of the repair process. This repair is rapid and well organised; it involves the recruitment of blood cells, the division of endogenous glial elements and, possibly, migration from pre-existing glial pools in adjacent ganglia. There are clear parallels between the events of repair and those of normal glial development. It seems likely that the ability of the insect central nervous system to repair resides in the retention of developmental capacities throughout its life and that damage results in the activation of this potential.

This record has no associated files available for download.

More information

Published date: February 1991

Identifiers

Local EPrints ID: 56021
URI: http://eprints.soton.ac.uk/id/eprint/56021
ISSN: 0265-9247
PURE UUID: 7497f3d6-d20a-4a62-866e-cf12f9662599
ORCID for David Shepherd: ORCID iD orcid.org/0000-0002-6961-7880

Catalogue record

Date deposited: 21 Aug 2008
Last modified: 06 Aug 2024 01:52

Export record

Altmetrics

Contributors

Author: Peter J.S. Smith
Author: David Shepherd ORCID iD
Author: John S. Edwards

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×