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Sarco(endo)plasmic reticulum calcium pumps: recent advances in our understanding of structure/function and biology (Review)

Sarco(endo)plasmic reticulum calcium pumps: recent advances in our understanding of structure/function and biology (Review)
Sarco(endo)plasmic reticulum calcium pumps: recent advances in our understanding of structure/function and biology (Review)
This review examines the structure and function of the sarco(endo)plasmic reticulum calcium pump (SERCA1a) in the light of the recent publication of the 2.6 resolution structure of this protein, and looks at the increasing awareness of the key role played by SERCAs in calcium signalling. The roles played by the calcium pump isoforms, SERCA1a/b, SERCA2a/b and SERCA3a/b/c in cellular function are discussed, and the modulation of SERCA activity by phospholamban, sarcolipin and other modulatory influences is examined. The recent discoveries of human SERCA mutations leading to disease states is reviewed, and the insights into SERCA function using transgenic approaches are outlined.
calcium, pumps, X-RAY, structure, genetic, diseas, Es, phospholamban, sarcolipin
0968-7688
189-200
East, J.M.
9fe7f794-1d89-4935-9a99-b831d786056e
East, J.M.
9fe7f794-1d89-4935-9a99-b831d786056e

East, J.M. (2000) Sarco(endo)plasmic reticulum calcium pumps: recent advances in our understanding of structure/function and biology (Review). Molecular Membrane Biology, 17 (4), 189-200. (doi:10.1080/09687680010009646).

Record type: Article

Abstract

This review examines the structure and function of the sarco(endo)plasmic reticulum calcium pump (SERCA1a) in the light of the recent publication of the 2.6 resolution structure of this protein, and looks at the increasing awareness of the key role played by SERCAs in calcium signalling. The roles played by the calcium pump isoforms, SERCA1a/b, SERCA2a/b and SERCA3a/b/c in cellular function are discussed, and the modulation of SERCA activity by phospholamban, sarcolipin and other modulatory influences is examined. The recent discoveries of human SERCA mutations leading to disease states is reviewed, and the insights into SERCA function using transgenic approaches are outlined.

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More information

Published date: 1 October 2000
Keywords: calcium, pumps, X-RAY, structure, genetic, diseas, Es, phospholamban, sarcolipin

Identifiers

Local EPrints ID: 56048
URI: https://eprints.soton.ac.uk/id/eprint/56048
ISSN: 0968-7688
PURE UUID: d9505feb-daf4-4b5e-80b0-5195d93d8ca7

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Date deposited: 08 Aug 2008
Last modified: 13 Mar 2019 20:35

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Author: J.M. East

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