The University of Southampton
University of Southampton Institutional Repository

Dynamic developmental expression of smallminded, a Drosophila gene required for cell division

Dynamic developmental expression of smallminded, a Drosophila gene required for cell division
Dynamic developmental expression of smallminded, a Drosophila gene required for cell division
Here we describe the expression pattern of the smallminded (smid) gene during Drosophila development and investigate the phenotype of a null mutant. In situ hybridisation reveals the ubiquitous expression of smid transcript throughout early embryonic stages until the extended germ band stage, after which expression becomes localised to the neurogenic ectoderm and gonad. Post-embryonic expression is restricted to tissues engaged in the developmental programme of the adult fly: the re-enlarged neuroblasts; imaginal discs; histoblast nests; and precursors of adult muscles. The correlation of smid expression with mitotic activity suggests a cell cycle function which is confirmed by the observed phenotype of a smid null mutant characterised by an abnormally small CNS, due to defective mitosis of post-embryonic neuroblasts and their subsequent death by apoptosis.
neuroblast, neurogenesis, cell cycle, aaa superfamily, cdc48, apoptosis
0925-4773
33-43
Long, Antony R.
51be2293-d395-478b-8b8f-1d44921ef611
Wilkins, Joanna C.
93f5cf24-d852-42db-aa0b-172595278708
Shepherd, David
11aa6858-d19c-4450-82ff-11dff9dcd9c4
Long, Antony R.
51be2293-d395-478b-8b8f-1d44921ef611
Wilkins, Joanna C.
93f5cf24-d852-42db-aa0b-172595278708
Shepherd, David
11aa6858-d19c-4450-82ff-11dff9dcd9c4

Long, Antony R., Wilkins, Joanna C. and Shepherd, David (1998) Dynamic developmental expression of smallminded, a Drosophila gene required for cell division. Mechanisms of Development, 76 (1-2), 33-43. (doi:10.1016/S0925-4773(98)00110-5).

Record type: Article

Abstract

Here we describe the expression pattern of the smallminded (smid) gene during Drosophila development and investigate the phenotype of a null mutant. In situ hybridisation reveals the ubiquitous expression of smid transcript throughout early embryonic stages until the extended germ band stage, after which expression becomes localised to the neurogenic ectoderm and gonad. Post-embryonic expression is restricted to tissues engaged in the developmental programme of the adult fly: the re-enlarged neuroblasts; imaginal discs; histoblast nests; and precursors of adult muscles. The correlation of smid expression with mitotic activity suggests a cell cycle function which is confirmed by the observed phenotype of a smid null mutant characterised by an abnormally small CNS, due to defective mitosis of post-embryonic neuroblasts and their subsequent death by apoptosis.

Full text not available from this repository.

More information

Published date: 1 August 1998
Keywords: neuroblast, neurogenesis, cell cycle, aaa superfamily, cdc48, apoptosis

Identifiers

Local EPrints ID: 56086
URI: https://eprints.soton.ac.uk/id/eprint/56086
ISSN: 0925-4773
PURE UUID: 3ffae565-b5df-47b9-919b-55ad6f124c35

Catalogue record

Date deposited: 21 Aug 2008
Last modified: 18 Feb 2019 17:31

Export record

Altmetrics

Contributors

Author: Antony R. Long
Author: Joanna C. Wilkins
Author: David Shepherd

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×