The University of Southampton
University of Southampton Institutional Repository

The acetylcholine induced membrane current fluctuations are characteristic of the receptor-ionophore population involved

Record type: Article

1. Clamp current recordings from voltage clamped Helix aspersa neurones show increased membrane current fluctuations during the three types of acetylcholine (ACh) response studied.
2. The variance of the ACh induced membrane current fluctuations was proportional to the mean clamp current and was steady during data acquisition. The mean channel current (iel) could be calculated from these values.
3. The power spectrum (PSD) of the ACh induced membrane current fluctuations for both the pure ionic responses [ACh D increased gNa+ and ACh H incrased gCl?] could be fitted by single Lorentzian curves.
4. The corner frequency (fc) of the PSD differed between the D and H responses, being 15.9 Hz and 48 Hz respectively, corresponding to mean channel open times (Tm) of 10 msec for the Na+ channel and 3.3 msec for the Cl? channel.
5. The PSD of the ACh induced membrane current fluctuations of the mixed ionic response [D(f Cl) increased gNa+ adn gCl?] could not be fitted by a single Lorentzian curve, but could be fitted by the arithmetic sum of two Lorentzian curves, with corner frequencies of 12.5 Hz and 50 Hz. These values for fc correspond to Tms of 15.9 msec and 3.2 msec.
6. It is suggested that the double Lorentzian of the D(f Cl) response is due to activation of a heterogeneous receptor-ionophore population consisting of two classes which correspond to the D receptor/Na+ ionophore and H receptor/Cl? ionophore present on the other cell types studied.

Full text not available from this repository.

Citation

Chad, J.E. and Kerkut, G.A. (1981) The acetylcholine induced membrane current fluctuations are characteristic of the receptor-ionophore population involved Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology, 68, (1), pp. 35-42. (doi:10.1016/0306-4492(81)90034-4).

More information

Published date: 1981

Identifiers

Local EPrints ID: 56145
URI: http://eprints.soton.ac.uk/id/eprint/56145
ISSN: 1532-0456
PURE UUID: 4bb49f49-c4cd-442b-8587-70f314e1686c
ORCID for J.E. Chad: ORCID iD orcid.org/0000-0001-6442-4281

Catalogue record

Date deposited: 22 Aug 2008
Last modified: 17 Jul 2017 14:31

Export record

Altmetrics

Contributors

Author: J.E. Chad ORCID iD
Author: G.A. Kerkut

University divisions


Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×