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The influence of mouse Ped gene expression on postnatal development

Watkins, Adam, Wilkins, Adrian, Osmond, Clive, Warner, Carol M., Comiskey, Martina, Hanson, Mark and Fleming, Tom P. (2006) The influence of mouse Ped gene expression on postnatal development The Journal of Physiology, 571, (1), pp. 211-220. (doi:10.1113/jphysiol.2005.099192).

Record type: Article


The Ped (preimplantation embryo development) gene, whose product is Qa-2 protein, is correlated with a faster rate of preimplantation development (Ped fast phenotype) in mice that express Qa-2 protein compared with mice with an absence of Qa-2 protein (Ped slow phenotype). In the current study, we have used two congenic mouse strains differentially expressing the Ped gene, strain B6.K1 (Ped slow; Qa-2 negative) and strain B6.K2 (Ped fast; Qa-2 positive), to investigate the effects of Ped gene expression on postnatal growth profiles, systolic blood pressure and adult organ allometry. At birth, B6.K1 mice were moderately lighter than B6.K2 mice. B6.K1 mice became heavier during postnatal life (P < 0.05) and had elevated systolic blood pressure at 21 weeks of age when compared with B6.K2 mice (P= 0.006). B6.K1 mice also demonstrated elevated serum angiotensin-converting enzyme (ACE) activity, a known regulator of blood pressure (P= 0.037). Altered organ:body weight ratios were also observed, with the B6.K1 females having a higher ratio for lungs than B6. K2 females (P= 0.014). These data provide evidence of an association between the rate of preimplantation embryo development, postnatal growth and later cardiovascular function.

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Published date: 15 February 2006
Organisations: Biological Sciences


Local EPrints ID: 56161
ISSN: 0022-3751
PURE UUID: 1bc17998-c739-4cc8-854b-4fd5e8a07918
ORCID for Clive Osmond: ORCID iD

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Date deposited: 07 Aug 2008
Last modified: 17 Jul 2017 14:31

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Author: Adam Watkins
Author: Adrian Wilkins
Author: Clive Osmond ORCID iD
Author: Carol M. Warner
Author: Martina Comiskey
Author: Mark Hanson
Author: Tom P. Fleming

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