The University of Southampton
University of Southampton Institutional Repository

The influence of mouse Ped gene expression on postnatal development

Watkins, Adam, Wilkins, Adrian, Osmond, Clive, Warner, Carol M., Comiskey, Martina, Hanson, Mark and Fleming, Tom P. (2006) The influence of mouse Ped gene expression on postnatal development The Journal of Physiology, 571, (1), pp. 211-220. (doi:10.1113/jphysiol.2005.099192).

Record type: Article

Abstract

The Ped (preimplantation embryo development) gene, whose product is Qa-2 protein, is correlated with a faster rate of preimplantation development (Ped fast phenotype) in mice that express Qa-2 protein compared with mice with an absence of Qa-2 protein (Ped slow phenotype). In the current study, we have used two congenic mouse strains differentially expressing the Ped gene, strain B6.K1 (Ped slow; Qa-2 negative) and strain B6.K2 (Ped fast; Qa-2 positive), to investigate the effects of Ped gene expression on postnatal growth profiles, systolic blood pressure and adult organ allometry. At birth, B6.K1 mice were moderately lighter than B6.K2 mice. B6.K1 mice became heavier during postnatal life (P < 0.05) and had elevated systolic blood pressure at 21 weeks of age when compared with B6.K2 mice (P= 0.006). B6.K1 mice also demonstrated elevated serum angiotensin-converting enzyme (ACE) activity, a known regulator of blood pressure (P= 0.037). Altered organ:body weight ratios were also observed, with the B6.K1 females having a higher ratio for lungs than B6. K2 females (P= 0.014). These data provide evidence of an association between the rate of preimplantation embryo development, postnatal growth and later cardiovascular function.

Full text not available from this repository.

More information

Published date: 15 February 2006
Organisations: Biological Sciences

Identifiers

Local EPrints ID: 56161
URI: http://eprints.soton.ac.uk/id/eprint/56161
ISSN: 0022-3751
PURE UUID: 1bc17998-c739-4cc8-854b-4fd5e8a07918
ORCID for Clive Osmond: ORCID iD orcid.org/0000-0002-9054-4655

Catalogue record

Date deposited: 07 Aug 2008
Last modified: 17 Jul 2017 14:31

Export record

Altmetrics

Contributors

Author: Adam Watkins
Author: Adrian Wilkins
Author: Clive Osmond ORCID iD
Author: Carol M. Warner
Author: Martina Comiskey
Author: Mark Hanson
Author: Tom P. Fleming

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×