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The influence of mouse Ped gene expression on postnatal development

The influence of mouse Ped gene expression on postnatal development
The influence of mouse Ped gene expression on postnatal development
The Ped (preimplantation embryo development) gene, whose product is Qa-2 protein, is correlated with a faster rate of preimplantation development (Ped fast phenotype) in mice that express Qa-2 protein compared with mice with an absence of Qa-2 protein (Ped slow phenotype). In the current study, we have used two congenic mouse strains differentially expressing the Ped gene, strain B6.K1 (Ped slow; Qa-2 negative) and strain B6.K2 (Ped fast; Qa-2 positive), to investigate the effects of Ped gene expression on postnatal growth profiles, systolic blood pressure and adult organ allometry. At birth, B6.K1 mice were moderately lighter than B6.K2 mice. B6.K1 mice became heavier during postnatal life (P < 0.05) and had elevated systolic blood pressure at 21 weeks of age when compared with B6.K2 mice (P= 0.006). B6.K1 mice also demonstrated elevated serum angiotensin-converting enzyme (ACE) activity, a known regulator of blood pressure (P= 0.037). Altered organ:body weight ratios were also observed, with the B6.K1 females having a higher ratio for lungs than B6. K2 females (P= 0.014). These data provide evidence of an association between the rate of preimplantation embryo development, postnatal growth and later cardiovascular function.
0022-3751
211-220
Watkins, Adam
508c5499-8046-41a3-804e-79799833418b
Wilkins, Adrian
71b5c44a-cbbd-4a42-bdff-dd7775970561
Osmond, Clive
2677bf85-494f-4a78-adf8-580e1b8acb81
Warner, Carol M.
1d6a8c76-50b7-401b-824a-b38517cd6dc0
Comiskey, Martina
e4e6124a-7fda-4d1f-ab80-352e9c713e6b
Hanson, Mark
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Fleming, Tom P.
2abf761a-e5a1-4fa7-a2c8-12e32d5d4c03
Watkins, Adam
508c5499-8046-41a3-804e-79799833418b
Wilkins, Adrian
71b5c44a-cbbd-4a42-bdff-dd7775970561
Osmond, Clive
2677bf85-494f-4a78-adf8-580e1b8acb81
Warner, Carol M.
1d6a8c76-50b7-401b-824a-b38517cd6dc0
Comiskey, Martina
e4e6124a-7fda-4d1f-ab80-352e9c713e6b
Hanson, Mark
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Fleming, Tom P.
2abf761a-e5a1-4fa7-a2c8-12e32d5d4c03

Watkins, Adam, Wilkins, Adrian, Osmond, Clive, Warner, Carol M., Comiskey, Martina, Hanson, Mark and Fleming, Tom P. (2006) The influence of mouse Ped gene expression on postnatal development. Journal of Physiology, 571 (1), 211-220. (doi:10.1113/jphysiol.2005.099192).

Record type: Article

Abstract

The Ped (preimplantation embryo development) gene, whose product is Qa-2 protein, is correlated with a faster rate of preimplantation development (Ped fast phenotype) in mice that express Qa-2 protein compared with mice with an absence of Qa-2 protein (Ped slow phenotype). In the current study, we have used two congenic mouse strains differentially expressing the Ped gene, strain B6.K1 (Ped slow; Qa-2 negative) and strain B6.K2 (Ped fast; Qa-2 positive), to investigate the effects of Ped gene expression on postnatal growth profiles, systolic blood pressure and adult organ allometry. At birth, B6.K1 mice were moderately lighter than B6.K2 mice. B6.K1 mice became heavier during postnatal life (P < 0.05) and had elevated systolic blood pressure at 21 weeks of age when compared with B6.K2 mice (P= 0.006). B6.K1 mice also demonstrated elevated serum angiotensin-converting enzyme (ACE) activity, a known regulator of blood pressure (P= 0.037). Altered organ:body weight ratios were also observed, with the B6.K1 females having a higher ratio for lungs than B6. K2 females (P= 0.014). These data provide evidence of an association between the rate of preimplantation embryo development, postnatal growth and later cardiovascular function.

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Published date: 15 February 2006
Organisations: Biological Sciences

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Local EPrints ID: 56161
URI: http://eprints.soton.ac.uk/id/eprint/56161
ISSN: 0022-3751
PURE UUID: 1bc17998-c739-4cc8-854b-4fd5e8a07918
ORCID for Clive Osmond: ORCID iD orcid.org/0000-0002-9054-4655
ORCID for Mark Hanson: ORCID iD orcid.org/0000-0002-6907-613X

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Date deposited: 07 Aug 2008
Last modified: 16 Mar 2024 03:17

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Contributors

Author: Adam Watkins
Author: Adrian Wilkins
Author: Clive Osmond ORCID iD
Author: Carol M. Warner
Author: Martina Comiskey
Author: Mark Hanson ORCID iD
Author: Tom P. Fleming

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