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Dietary protein restriction in the pregnant rat induces altered epigenetic regulation of the glucocorticoid receptor and peroxisomal proliferator-activated receptor alpha in the heart of the offspring which is prevented by folic acid.

Lillycrop, K.A., Phillips, E.S., Jackson, A.A., Hanson, M.A. and Burdge, G.C. (2006) Dietary protein restriction in the pregnant rat induces altered epigenetic regulation of the glucocorticoid receptor and peroxisomal proliferator-activated receptor alpha in the heart of the offspring which is prevented by folic acid. Proceedings of the Nutrition Society, 65, (OCA-B), p.65A. (doi:10.1017/S002966510600526X).

Record type: Article

Abstract

In healthy individuals, glucose and fatty acids are substrates for ATP generation in the heart. There is emerging evidence from patients with type 2 diabetes mellitus that preferential use of fatty acid b-oxidation for energy production may be linked to cardiomyopathy (Fink, 2004). PPARa activity is important for regulating fatty acid b-oxidation in the heart and is increased in hearts of rats with experimentally induced diabetes (Fink, 2004). Prenatal undernutrition is related inversely to risk of type 2 diabetes mellitus in man (Poole & Byrne, 2005) and insulin resistance in rats (Bertram & Hanson, 2001). We have shown that maternal dietary protein restriction induces persistent alterations to hepatic and carbohydrate metabolism in the offspring by altering the epigenetic regulation of PPARa and the glucocorticoid receptor (GR) (Lillycrop et al. 2005). Here we have tested the hypothesis that prenatal protein restriction induces hypomethylation of the GR and PPARa promoters in the heart, and that this is prevented by supplementation of the protein-restricted (PR) diet with folic acid.

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Published date: 1 January 2006
Organisations: Biological Sciences

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Local EPrints ID: 56173
URI: http://eprints.soton.ac.uk/id/eprint/56173
ISSN: 0029-6651
PURE UUID: b9e4f8db-c30c-41ae-bda7-aabdef1804b3
ORCID for K.A. Lillycrop: ORCID iD orcid.org/0000-0001-7350-5489
ORCID for E.S. Phillips: ORCID iD orcid.org/0000-0001-5268-4203
ORCID for G.C. Burdge: ORCID iD orcid.org/0000-0002-7665-2967

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Date deposited: 11 Aug 2008
Last modified: 17 Jul 2017 14:31

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Contributors

Author: K.A. Lillycrop ORCID iD
Author: E.S. Phillips ORCID iD
Author: A.A. Jackson
Author: M.A. Hanson
Author: G.C. Burdge ORCID iD

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