Calcium domains associated with individual channels can account for anomalous voltage relations of CA-dependent responses
Calcium domains associated with individual channels can account for anomalous voltage relations of CA-dependent responses
Computer-assisted modeling of calcium influx through voltage-activated membrane channels predicted that buffer-limited elevation of cytoplasmic free calcium ion concentration occurs within microscopic hemispherical "domains" centered upon the active Ca channels. With increasing depolarization, the number of activated channels, and hence the number of Ca domains, should increase; the single-channel current should, however, decrease, thereby decreasing Ca2+ accumulation in each domain relative to the macroscopic current. Such voltage dependence of the microscopic distribution of Ca2+ may influence relations between total Ca2+ entry and Ca-dependent processes. Ca-mediated inactivation of Ca channels in Aplysia neurons exhibits behavior consistent with the calcium domain hypothesis.
993-999
Chad, J.E.
d220e55e-3c13-4d1d-ae9a-1cfae8ccfbe1
Eckert, R.
f961a252-821d-49fa-ae48-590dd1502955
1984
Chad, J.E.
d220e55e-3c13-4d1d-ae9a-1cfae8ccfbe1
Eckert, R.
f961a252-821d-49fa-ae48-590dd1502955
Chad, J.E. and Eckert, R.
(1984)
Calcium domains associated with individual channels can account for anomalous voltage relations of CA-dependent responses.
Biophysical Journal, 45 (5), .
(doi:10.1016/S0006-3495(84)84244-7).
Abstract
Computer-assisted modeling of calcium influx through voltage-activated membrane channels predicted that buffer-limited elevation of cytoplasmic free calcium ion concentration occurs within microscopic hemispherical "domains" centered upon the active Ca channels. With increasing depolarization, the number of activated channels, and hence the number of Ca domains, should increase; the single-channel current should, however, decrease, thereby decreasing Ca2+ accumulation in each domain relative to the macroscopic current. Such voltage dependence of the microscopic distribution of Ca2+ may influence relations between total Ca2+ entry and Ca-dependent processes. Ca-mediated inactivation of Ca channels in Aplysia neurons exhibits behavior consistent with the calcium domain hypothesis.
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Published date: 1984
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Local EPrints ID: 56176
URI: http://eprints.soton.ac.uk/id/eprint/56176
ISSN: 0006-3495
PURE UUID: 5da4c050-8a89-4844-951e-094ec0fd2409
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Date deposited: 22 Aug 2008
Last modified: 16 Mar 2024 02:35
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Author:
R. Eckert
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