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Calcium domains associated with individual channels can account for anomalous voltage relations of CA-dependent responses

Chad, J.E. and Eckert, R. (1984) Calcium domains associated with individual channels can account for anomalous voltage relations of CA-dependent responses Biophysical Journal, 45, (5), pp. 993-999. (doi:10.1016/S0006-3495(84)84244-7).

Record type: Article

Abstract

Computer-assisted modeling of calcium influx through voltage-activated membrane channels predicted that buffer-limited elevation of cytoplasmic free calcium ion concentration occurs within microscopic hemispherical "domains" centered upon the active Ca channels. With increasing depolarization, the number of activated channels, and hence the number of Ca domains, should increase; the single-channel current should, however, decrease, thereby decreasing Ca2+ accumulation in each domain relative to the macroscopic current. Such voltage dependence of the microscopic distribution of Ca2+ may influence relations between total Ca2+ entry and Ca-dependent processes. Ca-mediated inactivation of Ca channels in Aplysia neurons exhibits behavior consistent with the calcium domain hypothesis.

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Published date: 1984

Identifiers

Local EPrints ID: 56176
URI: http://eprints.soton.ac.uk/id/eprint/56176
ISSN: 0006-3495
PURE UUID: 5da4c050-8a89-4844-951e-094ec0fd2409
ORCID for J.E. Chad: ORCID iD orcid.org/0000-0001-6442-4281

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Date deposited: 22 Aug 2008
Last modified: 17 Jul 2017 14:31

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Author: J.E. Chad ORCID iD
Author: R. Eckert

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