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MRI reveals that early changes in cerebral blood volume precede blood-brain barrier breakdown and overt pathology in MS-like lesions in rat brain

MRI reveals that early changes in cerebral blood volume precede blood-brain barrier breakdown and overt pathology in MS-like lesions in rat brain
MRI reveals that early changes in cerebral blood volume precede blood-brain barrier breakdown and overt pathology in MS-like lesions in rat brain
Magnetic resonance imaging (MRI) is an established clinical tool for diagnosing multiple sclerosis (MS), the archetypal central nervous system neuroinflammatory disease. In this study, we have used a model of delayed-type hypersensitivity in the rat brain, which bears many of the hallmarks of an MS lesion, to investigate the development of MRI-detectable changes before the appearance of conventional indices of lesion development. In addition, we have correlated the MRI-detectable changes with the developing histopathology. Significant increases in regional cerebral blood volume (rCBV) preceded overt changes in blood–brain barrier (BBB) permeability, T2 relaxation and the diffusion properties of tissue water. Thus, changes in rCBV might be a more sensitive indicator of lesion onset than the conventional indices used clinically in MS patients, such as contrast enhancement. In addition, we show that BBB breakdown, and consequent edema formation, are more closely correlated with astrogliosis than any other histopathologic changes, while regions of T1 and T2 hypointensity appear to reflect hypercellularity.
brain, cerebral blood volume, inflammation, magnetic resonance imaging, rat
204-216
Broom, Kerry A.
48ea5f70-5512-4616-9994-d31da056c3db
Anthony, Daniel C.
928249fa-dcf4-4088-b95b-ce14c719164d
Blamire, Andrew M.
9e32053d-5a8f-4358-b1c1-eb16e5d67b8d
Waters, Sara
98d640df-c057-462a-afb6-8ddecdc11c41
Styles, Peter
2a4bcc97-b4cb-45c2-807c-7f4e54b916d2
Perry, Victor Hugh
8f29d36a-8e1f-4082-8700-09483bbaeae4
Sibson, Nicola R.
408b5626-2da8-4fc8-9fb5-bbe52a7b8aaf
Broom, Kerry A.
48ea5f70-5512-4616-9994-d31da056c3db
Anthony, Daniel C.
928249fa-dcf4-4088-b95b-ce14c719164d
Blamire, Andrew M.
9e32053d-5a8f-4358-b1c1-eb16e5d67b8d
Waters, Sara
98d640df-c057-462a-afb6-8ddecdc11c41
Styles, Peter
2a4bcc97-b4cb-45c2-807c-7f4e54b916d2
Perry, Victor Hugh
8f29d36a-8e1f-4082-8700-09483bbaeae4
Sibson, Nicola R.
408b5626-2da8-4fc8-9fb5-bbe52a7b8aaf

Broom, Kerry A., Anthony, Daniel C., Blamire, Andrew M., Waters, Sara, Styles, Peter, Perry, Victor Hugh and Sibson, Nicola R. (2005) MRI reveals that early changes in cerebral blood volume precede blood-brain barrier breakdown and overt pathology in MS-like lesions in rat brain. Journal of Cerebral Blood Flow and Metabolism, 25 (2), 204-216. (doi:10.1038/sj.jcbfm.9600020).

Record type: Article

Abstract

Magnetic resonance imaging (MRI) is an established clinical tool for diagnosing multiple sclerosis (MS), the archetypal central nervous system neuroinflammatory disease. In this study, we have used a model of delayed-type hypersensitivity in the rat brain, which bears many of the hallmarks of an MS lesion, to investigate the development of MRI-detectable changes before the appearance of conventional indices of lesion development. In addition, we have correlated the MRI-detectable changes with the developing histopathology. Significant increases in regional cerebral blood volume (rCBV) preceded overt changes in blood–brain barrier (BBB) permeability, T2 relaxation and the diffusion properties of tissue water. Thus, changes in rCBV might be a more sensitive indicator of lesion onset than the conventional indices used clinically in MS patients, such as contrast enhancement. In addition, we show that BBB breakdown, and consequent edema formation, are more closely correlated with astrogliosis than any other histopathologic changes, while regions of T1 and T2 hypointensity appear to reflect hypercellularity.

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More information

Published date: February 2005
Keywords: brain, cerebral blood volume, inflammation, magnetic resonance imaging, rat

Identifiers

Local EPrints ID: 56186
URI: https://eprints.soton.ac.uk/id/eprint/56186
PURE UUID: 8e8e66d5-7e01-4bae-b5b9-1ff7d481258b

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Date deposited: 07 Aug 2008
Last modified: 13 Mar 2019 20:35

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