c-Myc represses the murine Nramp I promoter

Bowen, H., Biggs, T.E., Baker, S.T., Phillips, E., Perry, V.H., Mann, D.A. and Barton, C.H. (2002) c-Myc represses the murine Nramp I promoter Biochemical Society Transactions, 30, (4), pp. 774-777.


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The Nramp1 (natural resistance-associated macrophage protein 1) gene modulates the growth of intracellular pathogens and encodes a divalent cation transporter within lysosomes/late endosomes of macrophages. Nramp1 modulates the cytoplasmic iron pool. Wu, Polack and Dalla-Favera [(1999) Science 283, 676–679] showed reciprocal control of H-ferritin and IRP2 by c-Myc, and suggest that c-Myc regulates genes to increase cytoplasmic iron. A role for c-Myc in Nramp1 regulation was evaluated. Co-transfection studies show that c-Myc represses Nramp1 promoter function. Five non-canonical Myc-max binding sites (E-box) identified within the Nramp1 5´-flanking sequence are not responsible for the inhibitory effects of c-Myc on Nramp1 expression. An initiator(s) adjacent to the transcription-initiation site is a candidate for the inhibition observed. Results are consistent with a role for Nramp1 removing iron from the cytosol and antagonizing c-Myc function.

Item Type: Article
ISSNs: 0300-5127 (print)
Related URLs:
ePrint ID: 56214
Date :
Date Event
1 August 2002Published
Date Deposited: 06 Aug 2008
Last Modified: 16 Apr 2017 17:41
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/56214

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