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Creating porous tubes by centrifugal forces for soft tissue application

Dalton, Paul.D. and Shoichet, Molly.S. (2001) Creating porous tubes by centrifugal forces for soft tissue application Biomaterials, 22, (19), pp. 2661-2669. (doi:10.1016/S0142-9612(01)00008-4).

Record type: Article


Chemically crosslinked poly(2-hydroxyethyl methacrylate) (PHEMA) tubes were synthesized by applying centrifugal forces to propagating polymer chains in solution. Initiated monomer solutions, with a composition typical for PHEMA sponges, were placed into a cylindrical mold that was rotated about its long axis. As polymerization proceeded, phase separated PHEMA formed a sediment at the periphery under centrifugal action. The solvent remained in the center of the mold while the PHEMA phase gelled, resulting in a tube. By controlling the rotational speed and the formulation chemistry (i.e., monomer, initiator and crosslinking agent concentrations), the tube dimensions and wall morphology were manipulated. Tube manufacture was limited by a critical casting concentration [M]c, above which only rods formed. All tubes had an outer diameter of 2.4 mm, reflecting the internal diameter of the mold and a wall thickness of approximately 40–400 ?m. Wall morphologies varied from interconnecting polymer and water phases to a closed cell, gel-like, structure. Concentric tubes were successfully prepared by using formulations that enhanced phase separation over gelation/network formation. This was achieved by using formulations with lower concentrations of monomer and crosslinking agent and higher concentrations of initiator. This technique offers a new approach to the synthesis of polymeric tubes for use in soft tissue applications, such as nerve guidance channels.

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Published date: 1 October 2001
Keywords: poly(2-hydroxyethyl methacrylate), high gravity, hydrogel, phase separation, hollow fiber membrane, guidance channel


Local EPrints ID: 56277
ISSN: 0142-9612
PURE UUID: 08e83298-5971-4382-a80d-03faefa93e62

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Date deposited: 07 Aug 2008
Last modified: 17 Jul 2017 14:31

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Author: Paul.D. Dalton
Author: Molly.S. Shoichet

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