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Transcriptional control of Nramp 1: a paradigm for the repressive action of c-Myc

Lapham, A.S., Phillips, E.S. and Barton, C.H. (2004) Transcriptional control of Nramp 1: a paradigm for the repressive action of c-Myc Biochemical Society Transactions, 32, (6), pp. 1084-1086.

Record type: Article


Slc11a1/Nramp1 (solute carrier family 11 member a1/murine natural resistance-associated macrophage protein 1 gene) encodes a divalent cation transporter that resides within lysosomes/late endosomes of macrophages. Nramp1 modulates the cellular distribution of divalent cations in response to cell activation by intracellular pathogens. Nramp1 expression is repressed and activated by the proto-oncogene c-Myc and Miz-1 (c-Myc-interacting zinc finger protein 1) respectively. Here we demonstrate, using a c-Myc mutant (V394D, Val394Asp) that is incapable of binding Miz-1, that c-Myc repression of Nramp1 transcription is dependent on its interaction with Miz-1. An oligo pull-down assay demonstrates specific binding of recombinant Miz-1 to the Nramp1 Miz-1-binding site or initiator element(s), and Miz-1-dependent c-Myc recruitment.

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Published date: 1 December 2004


Local EPrints ID: 56294
ISSN: 0300-5127
PURE UUID: 518d5eb3-80bf-4407-adc6-456197120e15
ORCID for E.S. Phillips: ORCID iD

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Date deposited: 06 Aug 2008
Last modified: 17 Jul 2017 14:31

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Author: A.S. Lapham
Author: E.S. Phillips ORCID iD
Author: C.H. Barton

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