The University of Southampton
University of Southampton Institutional Repository

Pro-epileptic changes in synaptic function can be accompanied by pro-epileptic changes in neuronal excitability

Wheal, H.V., Bernard, C., Chad, J.E. and Cannon, R.C. (1998) Pro-epileptic changes in synaptic function can be accompanied by pro-epileptic changes in neuronal excitability Trends in Neurosciences, 21, (4), pp. 167-174. (doi:10.1016/S0166-2236(97)01182-X).

Record type: Article

Abstract

Repetitive sensory input, stroboscopic lights or repeated sounds can induce epileptic seizures in susceptible individuals. In order to understand the process we have to consider multiple factors. The output of a set of neurones is determined by the amount of excitatory synaptic input, the degree of positive feedback and their inherent electrical excitability, which can be modified by synaptic inhibition. Recent research has shown that it is possible to separate these phenomena, and that they do not always behave in unison.

Full text not available from this repository.

More information

Published date: 1 April 1998
Keywords: epilepsy, Ca2+ channels, sodium channels, NMDA receptors, AMPA receptors, synapses, E/S, LTP, LTD

Identifiers

Local EPrints ID: 56308
URI: http://eprints.soton.ac.uk/id/eprint/56308
PURE UUID: 63dcd104-897e-4bc8-ab6f-a6818fa0fe74
ORCID for J.E. Chad: ORCID iD orcid.org/0000-0001-6442-4281

Catalogue record

Date deposited: 22 Aug 2008
Last modified: 17 Jul 2017 14:31

Export record

Altmetrics

Contributors

Author: H.V. Wheal
Author: C. Bernard
Author: J.E. Chad ORCID iD
Author: R.C. Cannon

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×