Systemic infections and inflammation affect chronic neurodegeneration
Systemic infections and inflammation affect chronic neurodegeneration
It is well known that systemic infections cause flare-ups of disease in individuals with asthma and rheumatoid arthritis, and that relapses in multiple sclerosis can often be associated with upper respiratory-tract infections. Here we review evidence to support our hypothesis that in chronic neurodegenerative diseases such as Alzheimer's disease, with an ongoing innate immune response in the brain, systemic infections and inflammation can cause acute exacerbations of symptoms and drive the progression of neurodegeneration.
161-167
Perry, V.H.
8f29d36a-8e1f-4082-8700-09483bbaeae4
Cunningham, C.
6d675038-a4b1-46e2-9e4b-0a5ac27ea2b2
Holmes, C.
ada5abf3-8459-4cf7-be40-3f4e9391cc96
February 2007
Perry, V.H.
8f29d36a-8e1f-4082-8700-09483bbaeae4
Cunningham, C.
6d675038-a4b1-46e2-9e4b-0a5ac27ea2b2
Holmes, C.
ada5abf3-8459-4cf7-be40-3f4e9391cc96
Perry, V.H., Cunningham, C. and Holmes, C.
(2007)
Systemic infections and inflammation affect chronic neurodegeneration.
Nature Reviews Immunology, 7 (2), .
(doi:10.1038/nri2015).
Abstract
It is well known that systemic infections cause flare-ups of disease in individuals with asthma and rheumatoid arthritis, and that relapses in multiple sclerosis can often be associated with upper respiratory-tract infections. Here we review evidence to support our hypothesis that in chronic neurodegenerative diseases such as Alzheimer's disease, with an ongoing innate immune response in the brain, systemic infections and inflammation can cause acute exacerbations of symptoms and drive the progression of neurodegeneration.
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Published date: February 2007
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Local EPrints ID: 56335
URI: http://eprints.soton.ac.uk/id/eprint/56335
ISSN: 1474-1733
PURE UUID: 927db74e-4044-4ae4-8815-d231b0003515
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Date deposited: 08 Aug 2008
Last modified: 16 Mar 2024 03:07
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C. Cunningham
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