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Systemic infections and inflammation affect chronic neurodegeneration

Perry, V.H., Cunningham, C. and Holmes, C. (2007) Systemic infections and inflammation affect chronic neurodegeneration Nature Reviews Immunology, 7, (2), pp. 161-167. (doi:10.1038/nri2015).

Record type: Article

Abstract

It is well known that systemic infections cause flare-ups of disease in individuals with asthma and rheumatoid arthritis, and that relapses in multiple sclerosis can often be associated with upper respiratory-tract infections. Here we review evidence to support our hypothesis that in chronic neurodegenerative diseases such as Alzheimer's disease, with an ongoing innate immune response in the brain, systemic infections and inflammation can cause acute exacerbations of symptoms and drive the progression of neurodegeneration.

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Published date: February 2007

Identifiers

Local EPrints ID: 56335
URI: http://eprints.soton.ac.uk/id/eprint/56335
ISSN: 1474-1733
PURE UUID: 927db74e-4044-4ae4-8815-d231b0003515

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Date deposited: 08 Aug 2008
Last modified: 17 Jul 2017 14:31

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Contributors

Author: V.H. Perry
Author: C. Cunningham
Author: C. Holmes

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