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The effect of the anthelmintic emodepside at the neuromuscular junction of the parasitic nematode Ascaris suum

Willson, J., Amliwala, K., Harder, A., Holden-Dye, L. and Walker, R.J. (2003) The effect of the anthelmintic emodepside at the neuromuscular junction of the parasitic nematode Ascaris suum Parasitology, 126, (1), pp. 79-86. (doi:10.1017/S0031182002002639).

Record type: Article


Here we report on the action of the novel cyclo-depsipeptide anthelmintic, emodepside, on the body wall muscle of the parasitic nematode, Ascaris suum. Emodepside caused (i) muscle relaxation, (ii) inhibition of muscle contraction elicited by either acetylcholine (ACh), or the neuropeptide, AF2 (KHEYLRFamide) and (iii) a rapid relaxation of muscle tonically contracted by ACh. The inhibitory action of emodepside on the response to ACh was not observed in a denervated muscle strip, indicating that it may exert this action through the nerve cord, and not directly on the muscle. Electrophysiological recordings showed emodepside elicited a Ca++-dependent hyperpolarization of muscle cells. Furthermore, the response to emodepside was dependent on extracellular K+, similar to the action of the inhibitory neuropeptides PF1 and PF2 (SDPNFLRFamide and SADPNFLRFamide). Thus emodepside may act at the neuromuscular junction to stimulate release of an inhibitory neurotransmitter or neuromodulator, with a similar action to the PF1/PF2 neuropeptides.

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Published date: January 2003
Keywords: anthelmintic, ascaris suum, neuropeptide


Local EPrints ID: 56382
ISSN: 0031-1820
PURE UUID: dfe95d11-0ea0-4b9d-8493-0e70e369effa

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Date deposited: 08 Aug 2008
Last modified: 17 Jul 2017 14:31

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Author: J. Willson
Author: K. Amliwala
Author: A. Harder
Author: L. Holden-Dye
Author: R.J. Walker

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