Ca2+ transport by the synaptosomal plasma membrane Ca2+-ATPase and the effect of thioridazine
Ca2+ transport by the synaptosomal plasma membrane Ca2+-ATPase and the effect of thioridazine
Thioridazine inhibits the activity of the synaptic plasma membrane Ca2+-ATPase from pig brain and slightly decreases the rate of Ca2+ accumulation by synaptic plasma membrane vesicles in the absence of phosphate. However, in the presence of phosphate, thioridazine increases the rate of Ca2+ accumulation into synaptic plasma membrane vesicles. Phosphate anions diffuse through the membrane and form calcium phosphate crystals, reducing the free Ca2+ concentration inside the vesicles and the rate of Ca2+ leak. The higher levels of Ca2+ accumulation obtained in the presence of thioridazine could be explained by a reduction of the rate of slippage on the plasma membrane ATPase.
2353-2358
Palacios, J.
42a7b04f-31bc-4f95-a0c4-05039986443d
Sepulveda, M.R.
01c8ce7b-36c8-45f1-bb85-7be39ad871e8
Lee, A.G.
0891914c-e0e2-4ee1-b43e-1b70eb072d8e
Mata, A.M.
154af8bf-aabd-4dce-b757-05955f33d326
1 March 2004
Palacios, J.
42a7b04f-31bc-4f95-a0c4-05039986443d
Sepulveda, M.R.
01c8ce7b-36c8-45f1-bb85-7be39ad871e8
Lee, A.G.
0891914c-e0e2-4ee1-b43e-1b70eb072d8e
Mata, A.M.
154af8bf-aabd-4dce-b757-05955f33d326
Palacios, J., Sepulveda, M.R., Lee, A.G. and Mata, A.M.
(2004)
Ca2+ transport by the synaptosomal plasma membrane Ca2+-ATPase and the effect of thioridazine.
Biochemistry, 43 (8), .
(doi:10.1021/bi0359473).
Abstract
Thioridazine inhibits the activity of the synaptic plasma membrane Ca2+-ATPase from pig brain and slightly decreases the rate of Ca2+ accumulation by synaptic plasma membrane vesicles in the absence of phosphate. However, in the presence of phosphate, thioridazine increases the rate of Ca2+ accumulation into synaptic plasma membrane vesicles. Phosphate anions diffuse through the membrane and form calcium phosphate crystals, reducing the free Ca2+ concentration inside the vesicles and the rate of Ca2+ leak. The higher levels of Ca2+ accumulation obtained in the presence of thioridazine could be explained by a reduction of the rate of slippage on the plasma membrane ATPase.
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Submitted date: 31 October 2003
Published date: 1 March 2004
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Local EPrints ID: 56437
URI: http://eprints.soton.ac.uk/id/eprint/56437
ISSN: 0006-2960
PURE UUID: c2d40d6f-ae17-4557-846f-3bf268f02717
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Date deposited: 07 Aug 2008
Last modified: 15 Mar 2024 11:01
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Author:
J. Palacios
Author:
M.R. Sepulveda
Author:
A.M. Mata
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