Ca2+ transport by the synaptosomal plasma membrane Ca2+-ATPase and the effect of thioridazine


Palacios, J., Sepulveda, M.R., Lee, A.G. and Mata, A.M. (2004) Ca2+ transport by the synaptosomal plasma membrane Ca2+-ATPase and the effect of thioridazine Biochemistry, 43, (8), pp. 2353-2358. (doi:10.1021/bi0359473).

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Description/Abstract

Thioridazine inhibits the activity of the synaptic plasma membrane Ca2+-ATPase from pig brain and slightly decreases the rate of Ca2+ accumulation by synaptic plasma membrane vesicles in the absence of phosphate. However, in the presence of phosphate, thioridazine increases the rate of Ca2+ accumulation into synaptic plasma membrane vesicles. Phosphate anions diffuse through the membrane and form calcium phosphate crystals, reducing the free Ca2+ concentration inside the vesicles and the rate of Ca2+ leak. The higher levels of Ca2+ accumulation obtained in the presence of thioridazine could be explained by a reduction of the rate of slippage on the plasma membrane ATPase.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1021/bi0359473
ISSNs: 0006-2960 (print)
Subjects:
ePrint ID: 56437
Date :
Date Event
31 October 2003Submitted
1 March 2004Published
Date Deposited: 07 Aug 2008
Last Modified: 16 Apr 2017 17:41
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/56437

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