The University of Southampton
University of Southampton Institutional Repository

Ca2+ transport by the synaptosomal plasma membrane Ca2+-ATPase and the effect of thioridazine

Palacios, J., Sepulveda, M.R., Lee, A.G. and Mata, A.M. (2004) Ca2+ transport by the synaptosomal plasma membrane Ca2+-ATPase and the effect of thioridazine Biochemistry, 43, (8), pp. 2353-2358. (doi:10.1021/bi0359473).

Record type: Article

Abstract

Thioridazine inhibits the activity of the synaptic plasma membrane Ca2+-ATPase from pig brain and slightly decreases the rate of Ca2+ accumulation by synaptic plasma membrane vesicles in the absence of phosphate. However, in the presence of phosphate, thioridazine increases the rate of Ca2+ accumulation into synaptic plasma membrane vesicles. Phosphate anions diffuse through the membrane and form calcium phosphate crystals, reducing the free Ca2+ concentration inside the vesicles and the rate of Ca2+ leak. The higher levels of Ca2+ accumulation obtained in the presence of thioridazine could be explained by a reduction of the rate of slippage on the plasma membrane ATPase.

Full text not available from this repository.

More information

Submitted date: 31 October 2003
Published date: 1 March 2004

Identifiers

Local EPrints ID: 56437
URI: http://eprints.soton.ac.uk/id/eprint/56437
ISSN: 0006-2960
PURE UUID: c2d40d6f-ae17-4557-846f-3bf268f02717

Catalogue record

Date deposited: 07 Aug 2008
Last modified: 11 Jul 2017 09:46

Export record

Altmetrics

Contributors

Author: J. Palacios
Author: M.R. Sepulveda
Author: A.G. Lee
Author: A.M. Mata

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×