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Ca2+ transport by the synaptosomal plasma membrane Ca2+-ATPase and the effect of thioridazine

Palacios, J., Sepulveda, M.R., Lee, A.G. and Mata, A.M. (2004) Ca2+ transport by the synaptosomal plasma membrane Ca2+-ATPase and the effect of thioridazine Biochemistry, 43, (8), pp. 2353-2358. (doi:10.1021/bi0359473).

Record type: Article


Thioridazine inhibits the activity of the synaptic plasma membrane Ca2+-ATPase from pig brain and slightly decreases the rate of Ca2+ accumulation by synaptic plasma membrane vesicles in the absence of phosphate. However, in the presence of phosphate, thioridazine increases the rate of Ca2+ accumulation into synaptic plasma membrane vesicles. Phosphate anions diffuse through the membrane and form calcium phosphate crystals, reducing the free Ca2+ concentration inside the vesicles and the rate of Ca2+ leak. The higher levels of Ca2+ accumulation obtained in the presence of thioridazine could be explained by a reduction of the rate of slippage on the plasma membrane ATPase.

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Submitted date: 31 October 2003
Published date: 1 March 2004


Local EPrints ID: 56437
ISSN: 0006-2960
PURE UUID: c2d40d6f-ae17-4557-846f-3bf268f02717

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Date deposited: 07 Aug 2008
Last modified: 11 Jul 2017 09:46

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Author: J. Palacios
Author: M.R. Sepulveda
Author: A.G. Lee
Author: A.M. Mata

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