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Sequence effects of single base loops in intramolecular quadruplex DNA

Record type: Article

We have examined the properties of intramolecular G-quadruplexes in which the G3 tracts are separated by single base loops. The most stable complex contained 1?,2?-dideoxyribose in all three loops, while loops containing T and C were slightly less stable (by about 2°C). Quadruplexes containing loops with single A residues were less stable by 8°C for each T to A substitution. These folded sequences display similar CD spectra, which are consistent with the formation of parallel stranded complexes with double-chain reversal loops. These results demonstrate that loop sequence, and not just length, affects quadruplex stability.

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Citation

Rachwal, Phillip A., Brown, Tom and Fox, Keith R. (2007) Sequence effects of single base loops in intramolecular quadruplex DNA Febs Letters, 581, (8), pp. 1657-1660. (doi:10.1016/j.febslet.2007.03.040).

More information

Submitted date: 7 February 2007
Published date: 17 April 2007
Keywords: dna quadruplex, dna structure

Identifiers

Local EPrints ID: 56440
URI: http://eprints.soton.ac.uk/id/eprint/56440
ISSN: 0014-5793
PURE UUID: 22e29e91-3956-4cee-82ec-190f62fa5e34
ORCID for Keith R. Fox: ORCID iD orcid.org/0000-0002-2925-7315

Catalogue record

Date deposited: 07 Aug 2008
Last modified: 17 Jul 2017 14:30

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Contributors

Author: Phillip A. Rachwal
Author: Tom Brown
Author: Keith R. Fox ORCID iD

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