Rachwal, Phillip A., Brown, Tom and Fox, Keith R.
Sequence effects of single base loops in intramolecular quadruplex DNA
Febs Letters, 581, (8), . (doi:10.1016/j.febslet.2007.03.040).
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We have examined the properties of intramolecular G-quadruplexes in which the G3 tracts are separated by single base loops. The most stable complex contained 1?,2?-dideoxyribose in all three loops, while loops containing T and C were slightly less stable (by about 2°C). Quadruplexes containing loops with single A residues were less stable by 8°C for each T to A substitution. These folded sequences display similar CD spectra, which are consistent with the formation of parallel stranded complexes with double-chain reversal loops. These results demonstrate that loop sequence, and not just length, affects quadruplex stability.
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