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Sequence effects of single base loops in intramolecular quadruplex DNA

Rachwal, Phillip A., Brown, Tom and Fox, Keith R. (2007) Sequence effects of single base loops in intramolecular quadruplex DNA Febs Letters, 581, (8), pp. 1657-1660. (doi:10.1016/j.febslet.2007.03.040).

Record type: Article


We have examined the properties of intramolecular G-quadruplexes in which the G3 tracts are separated by single base loops. The most stable complex contained 1?,2?-dideoxyribose in all three loops, while loops containing T and C were slightly less stable (by about 2°C). Quadruplexes containing loops with single A residues were less stable by 8°C for each T to A substitution. These folded sequences display similar CD spectra, which are consistent with the formation of parallel stranded complexes with double-chain reversal loops. These results demonstrate that loop sequence, and not just length, affects quadruplex stability.

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Submitted date: 7 February 2007
Published date: 17 April 2007
Keywords: dna quadruplex, dna structure


Local EPrints ID: 56440
ISSN: 0014-5793
PURE UUID: 22e29e91-3956-4cee-82ec-190f62fa5e34
ORCID for Keith R. Fox: ORCID iD

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Date deposited: 07 Aug 2008
Last modified: 17 Jul 2017 14:30

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Author: Phillip A. Rachwal
Author: Tom Brown
Author: Keith R. Fox ORCID iD

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