Persistent pathogens in the parenchyma of the brain
Persistent pathogens in the parenchyma of the brain
It has recently been shown that bacteria and viruses can be delivered to the brain parenchyma without evoking an immune response. These experiments demonstrate that there are no cells within the brain parenchyma that can initiate a primary immune response, and that the drainage of pathogens from the brain parenchyma is distinct from that documented for soluble proteins. A persistent pathogen in the brain parenchyma can become a target for the immune system following peripheral sensitisation, and this may lead to bystander tissue damage. These observations may have consequences for vaccination of persons with central nervous system HIV infection.
brain, antigen presenting cell, pathogen, dendritic cell
S86-S89
Perry, V. Hugh
8f29d36a-8e1f-4082-8700-09483bbaeae4
May 2000
Perry, V. Hugh
8f29d36a-8e1f-4082-8700-09483bbaeae4
Perry, V. Hugh
(2000)
Persistent pathogens in the parenchyma of the brain.
Journal of Neurovirology, 6 (Supplement 1), .
Abstract
It has recently been shown that bacteria and viruses can be delivered to the brain parenchyma without evoking an immune response. These experiments demonstrate that there are no cells within the brain parenchyma that can initiate a primary immune response, and that the drainage of pathogens from the brain parenchyma is distinct from that documented for soluble proteins. A persistent pathogen in the brain parenchyma can become a target for the immune system following peripheral sensitisation, and this may lead to bystander tissue damage. These observations may have consequences for vaccination of persons with central nervous system HIV infection.
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Published date: May 2000
Keywords:
brain, antigen presenting cell, pathogen, dendritic cell
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Local EPrints ID: 56449
URI: http://eprints.soton.ac.uk/id/eprint/56449
ISSN: 1355-0284
PURE UUID: 6c8ddcf7-7e9e-489f-a12a-d4c9af4db900
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Date deposited: 22 Aug 2008
Last modified: 22 Jul 2022 21:07
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