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Persistent pathogens in the parenchyma of the brain

Persistent pathogens in the parenchyma of the brain
Persistent pathogens in the parenchyma of the brain
It has recently been shown that bacteria and viruses can be delivered to the brain parenchyma without evoking an immune response. These experiments demonstrate that there are no cells within the brain parenchyma that can initiate a primary immune response, and that the drainage of pathogens from the brain parenchyma is distinct from that documented for soluble proteins. A persistent pathogen in the brain parenchyma can become a target for the immune system following peripheral sensitisation, and this may lead to bystander tissue damage. These observations may have consequences for vaccination of persons with central nervous system HIV infection.
brain, antigen presenting cell, pathogen, dendritic cell
1355-0284
S86-S89
Perry, V. Hugh
8f29d36a-8e1f-4082-8700-09483bbaeae4
Perry, V. Hugh
8f29d36a-8e1f-4082-8700-09483bbaeae4

Perry, V. Hugh (2000) Persistent pathogens in the parenchyma of the brain. Journal of NeuroVirology, 6 (Supplement 1), S86-S89.

Record type: Article

Abstract

It has recently been shown that bacteria and viruses can be delivered to the brain parenchyma without evoking an immune response. These experiments demonstrate that there are no cells within the brain parenchyma that can initiate a primary immune response, and that the drainage of pathogens from the brain parenchyma is distinct from that documented for soluble proteins. A persistent pathogen in the brain parenchyma can become a target for the immune system following peripheral sensitisation, and this may lead to bystander tissue damage. These observations may have consequences for vaccination of persons with central nervous system HIV infection.

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More information

Published date: May 2000
Keywords: brain, antigen presenting cell, pathogen, dendritic cell

Identifiers

Local EPrints ID: 56449
URI: https://eprints.soton.ac.uk/id/eprint/56449
ISSN: 1355-0284
PURE UUID: 6c8ddcf7-7e9e-489f-a12a-d4c9af4db900

Catalogue record

Date deposited: 22 Aug 2008
Last modified: 13 Mar 2019 20:35

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