The University of Southampton
University of Southampton Institutional Repository

Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors

Melyan, Z., Lancaster, B. and Wheal, H.V. (2004) Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors Journal of Neuroscience, 24, (19), pp. 4530-4534. (doi:10.1523/JNEUROSCI.5356-03.2004).

Record type: Article

Abstract

Prolonged modification of intrinsic neuronal excitability is gaining prominence as an activity-dependent form of plasticity. Here we describe a potential synaptic initiation mechanism for these changes in which release of the transmitter glutamate acts on kainate receptors to regulate the postspike slow afterhyperpolarization (sAHP). This action of synaptically released glutamate was occluded by previous kainate application. Furthermore, inhibition of glutamate uptake enhanced the effects of synaptic activation. Glutamate-mediated kainate receptor inhibition of sAHP current (IsAHP) was blocked by the PKC inhibitor calphostin C, confirming the requirement for a metabotropic signaling cascade. These data describe a new physiological function for glutamate release: activation of metabotropic kainate receptors, which control directly the excitability of pyramidal cells and probably contribute to prolonged excitability changes.

Full text not available from this repository.

More information

Submitted date: 4 December 2003
Published date: 1 May 2004

Identifiers

Local EPrints ID: 56468
URI: http://eprints.soton.ac.uk/id/eprint/56468
ISSN: 0270-6474
PURE UUID: cbe76f9f-4acd-4a40-9131-fd159e7fbd62

Catalogue record

Date deposited: 08 Aug 2008
Last modified: 17 Jul 2017 14:30

Export record

Altmetrics

Contributors

Author: Z. Melyan
Author: B. Lancaster
Author: H.V. Wheal

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×