Ras, PI3-kinase and mTOR signaling in cardiac hypertrophy

Proud, C.G. (2004) Ras, PI3-kinase and mTOR signaling in cardiac hypertrophy Cardiovascular Research, 63, (3), pp. 403-413. (doi:10.1016/j.cardiores.2004.02.003).


Full text not available from this repository.


Cardiac hypertrophy involves increased mass (growth) of the heart and a cardinal feature of this condition is increased rates of protein synthesis. Several signaling pathways have been implicated in cardiac hypertrophy including the phosphatidylinositol 3-kinase (PI3K) and Ras/Raf/MEK/Erk pathways. PI3K lies upstream of the mammalian target of rapamycin (mTOR), an important positive regulator of protein synthesis and cell growth. However, recent data suggest that, in response to certain hypertrophic agents, signaling via Ras and MEK/Erk, as well as mTOR, is required for activation of protein synthesis, indicating new connections between these key signaling pathways.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/j.cardiores.2004.02.003
ISSNs: 0008-6363 (print)
Keywords: hypertrophy, ras, MAP kinase, PI3-kinase, protein synthesis, mTOR, mRNA translation
ePrint ID: 56499
Date :
Date Event
1 August 2004Published
Date Deposited: 07 Aug 2008
Last Modified: 16 Apr 2017 17:41
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/56499

Actions (login required)

View Item View Item