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Ras, PI3-kinase and mTOR signaling in cardiac hypertrophy

Record type: Article

Cardiac hypertrophy involves increased mass (growth) of the heart and a cardinal feature of this condition is increased rates of protein synthesis. Several signaling pathways have been implicated in cardiac hypertrophy including the phosphatidylinositol 3-kinase (PI3K) and Ras/Raf/MEK/Erk pathways. PI3K lies upstream of the mammalian target of rapamycin (mTOR), an important positive regulator of protein synthesis and cell growth. However, recent data suggest that, in response to certain hypertrophic agents, signaling via Ras and MEK/Erk, as well as mTOR, is required for activation of protein synthesis, indicating new connections between these key signaling pathways.

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Citation

Proud, C.G. (2004) Ras, PI3-kinase and mTOR signaling in cardiac hypertrophy Cardiovascular Research, 63, (3), pp. 403-413. (doi:10.1016/j.cardiores.2004.02.003).

More information

Published date: 1 August 2004
Keywords: hypertrophy, ras, MAP kinase, PI3-kinase, protein synthesis, mTOR, mRNA translation

Identifiers

Local EPrints ID: 56499
URI: http://eprints.soton.ac.uk/id/eprint/56499
ISSN: 0008-6363
PURE UUID: 3a84c87b-5e43-4bf1-8da8-2446e988faea

Catalogue record

Date deposited: 07 Aug 2008
Last modified: 17 Jul 2017 14:30

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Contributors

Author: C.G. Proud

University divisions


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