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Ras, PI3-kinase and mTOR signaling in cardiac hypertrophy

Proud, C.G. (2004) Ras, PI3-kinase and mTOR signaling in cardiac hypertrophy Cardiovascular Research, 63, (3), pp. 403-413. (doi:10.1016/j.cardiores.2004.02.003).

Record type: Article


Cardiac hypertrophy involves increased mass (growth) of the heart and a cardinal feature of this condition is increased rates of protein synthesis. Several signaling pathways have been implicated in cardiac hypertrophy including the phosphatidylinositol 3-kinase (PI3K) and Ras/Raf/MEK/Erk pathways. PI3K lies upstream of the mammalian target of rapamycin (mTOR), an important positive regulator of protein synthesis and cell growth. However, recent data suggest that, in response to certain hypertrophic agents, signaling via Ras and MEK/Erk, as well as mTOR, is required for activation of protein synthesis, indicating new connections between these key signaling pathways.

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Published date: 1 August 2004
Keywords: hypertrophy, ras, MAP kinase, PI3-kinase, protein synthesis, mTOR, mRNA translation


Local EPrints ID: 56499
ISSN: 0008-6363
PURE UUID: 3a84c87b-5e43-4bf1-8da8-2446e988faea

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Date deposited: 07 Aug 2008
Last modified: 17 Jul 2017 14:30

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Author: C.G. Proud

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