Disconnected mutants show disruption to the central projections of proprioceptive neurons in Drosophila melanogaster
Disconnected mutants show disruption to the central projections of proprioceptive neurons in Drosophila melanogaster
We used a P[GAL4] enhancer-trap line, C161, in conjunction with the UAS-lacZ reporter construct to visualize the central projections of a defined set of thoracic and abdominal sensory neurons in a disconnected (disco) mutant background. The results show defects in the organization of sensory axons in the larval and adult central nervous system. The defects are indicative of problems with axon growth and development and include (a) poor axon fasciculation, (b) aberrant axon growth, (c) excessive terminal branching, and (d) ectopic innervation. Sensory neuron identity appears to be normal. The defects are comparable to those previously described for larval photoreceptor and adult retinular cells in disco mutants and extend the known effects of this mutation. Reduced larval and adult viability are likely to result from locomotory defects related to the disruption of the sensory system.
enhancer-trap, sensory neuron, development, axon growth, Locomotion/physiology, Animals, Larva/physiology, Mutation/physiology, Neural Pathways/cytology, Pupa/physiology, Proprioception/genetics, Neurons, Afferent/physiology
337-347
Glossop, N.R.J.
82026fcd-9264-4731-b0d8-9b6ec7bf3735
Shepherd, D.
11aa6858-d19c-4450-82ff-11dff9dcd9c4
6 January 1999
Glossop, N.R.J.
82026fcd-9264-4731-b0d8-9b6ec7bf3735
Shepherd, D.
11aa6858-d19c-4450-82ff-11dff9dcd9c4
Abstract
We used a P[GAL4] enhancer-trap line, C161, in conjunction with the UAS-lacZ reporter construct to visualize the central projections of a defined set of thoracic and abdominal sensory neurons in a disconnected (disco) mutant background. The results show defects in the organization of sensory axons in the larval and adult central nervous system. The defects are indicative of problems with axon growth and development and include (a) poor axon fasciculation, (b) aberrant axon growth, (c) excessive terminal branching, and (d) ectopic innervation. Sensory neuron identity appears to be normal. The defects are comparable to those previously described for larval photoreceptor and adult retinular cells in disco mutants and extend the known effects of this mutation. Reduced larval and adult viability are likely to result from locomotory defects related to the disruption of the sensory system.
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Published date: 6 January 1999
Keywords:
enhancer-trap, sensory neuron, development, axon growth, Locomotion/physiology, Animals, Larva/physiology, Mutation/physiology, Neural Pathways/cytology, Pupa/physiology, Proprioception/genetics, Neurons, Afferent/physiology
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Local EPrints ID: 56511
URI: http://eprints.soton.ac.uk/id/eprint/56511
ISSN: 0022-3034
PURE UUID: e3bb226a-a1ca-4ac7-b054-6adb10f03584
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Date deposited: 22 Aug 2008
Last modified: 06 Aug 2024 01:52
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Author:
N.R.J. Glossop
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