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Disconnected mutants show disruption to the central projections of proprioceptive neurons in Drosophila melanogaster

Glossop, N.R.J. and Shepherd, D. (1999) Disconnected mutants show disruption to the central projections of proprioceptive neurons in Drosophila melanogaster Journal of Neurobiology, 36, (3), pp. 337-347. (doi:10.1002/(SICI)1097-4695(19980905)36:3<337::AID-NEU3>3.0.CO;2-X).

Record type: Article

Abstract

We used a P[GAL4] enhancer-trap line, C161, in conjunction with the UAS-lacZ reporter construct to visualize the central projections of a defined set of thoracic and abdominal sensory neurons in a disconnected (disco) mutant background. The results show defects in the organization of sensory axons in the larval and adult central nervous system. The defects are indicative of problems with axon growth and development and include (a) poor axon fasciculation, (b) aberrant axon growth, (c) excessive terminal branching, and (d) ectopic innervation. Sensory neuron identity appears to be normal. The defects are comparable to those previously described for larval photoreceptor and adult retinular cells in disco mutants and extend the known effects of this mutation. Reduced larval and adult viability are likely to result from locomotory defects related to the disruption of the sensory system.

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More information

Published date: 6 January 1999
Keywords: enhancer-trap, sensory neuron, development, axon growth, locomotion

Identifiers

Local EPrints ID: 56511
URI: http://eprints.soton.ac.uk/id/eprint/56511
ISSN: 0022-3034
PURE UUID: e3bb226a-a1ca-4ac7-b054-6adb10f03584

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Date deposited: 22 Aug 2008
Last modified: 17 Jul 2017 14:30

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Contributors

Author: N.R.J. Glossop
Author: D. Shepherd

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