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Synaptic release rather than failure in the conditioning pulse results in paired-pulse facilitation during minimal synaptic stimulation in the rat hippocampal CA1 neurones

Synaptic release rather than failure in the conditioning pulse results in paired-pulse facilitation during minimal synaptic stimulation in the rat hippocampal CA1 neurones
Synaptic release rather than failure in the conditioning pulse results in paired-pulse facilitation during minimal synaptic stimulation in the rat hippocampal CA1 neurones
In this paper we report our observations of the relationship of paired-pulse facilitation (PPF) with synaptic release or release failure at small numbers of synaptic sites. Minimal stimulation protocols were employed to enable the activation of only one or a few axons which synapse onto CAI pyramidal cells in the hippocampus. Excitatory postsynaptic currents (EPSCs) in response to paired stimulation were measured. On the analysis of the data, we examined the effects of failure and synaptic release on PPF, and found that PPF was observed as a decrease in failures of synaptic release in response to test stimuli which were preceded by conditioning stimuli that evoked synaptic release. The test-pulse failure rate following conditioning pulse failures was indistinguishable from the overall conditioning pulse failure rate. It is postulated that the mechanism of paired-pulse facilitation is presynaptic and associated with successful synaptic release in response to the conditioning stimulus.
hippocampus, presynaptic release, paired-pulse facilitation, calcium
0304-3940
204-208
Chen, Y.
aa3aa967-2aa4-499c-9265-8e6a7e7fb9e5
Chad, J.E.
d220e55e-3c13-4d1d-ae9a-1cfae8ccfbe1
Wheal, H.V.
50ba5833-9920-407a-a48a-1fe917534b74
Chen, Y.
aa3aa967-2aa4-499c-9265-8e6a7e7fb9e5
Chad, J.E.
d220e55e-3c13-4d1d-ae9a-1cfae8ccfbe1
Wheal, H.V.
50ba5833-9920-407a-a48a-1fe917534b74

Chen, Y., Chad, J.E. and Wheal, H.V. (1996) Synaptic release rather than failure in the conditioning pulse results in paired-pulse facilitation during minimal synaptic stimulation in the rat hippocampal CA1 neurones. Neuroscience Letters, 218 (3), 204-208. (doi:10.1016/S0304-3940(96)13149-9).

Record type: Article

Abstract

In this paper we report our observations of the relationship of paired-pulse facilitation (PPF) with synaptic release or release failure at small numbers of synaptic sites. Minimal stimulation protocols were employed to enable the activation of only one or a few axons which synapse onto CAI pyramidal cells in the hippocampus. Excitatory postsynaptic currents (EPSCs) in response to paired stimulation were measured. On the analysis of the data, we examined the effects of failure and synaptic release on PPF, and found that PPF was observed as a decrease in failures of synaptic release in response to test stimuli which were preceded by conditioning stimuli that evoked synaptic release. The test-pulse failure rate following conditioning pulse failures was indistinguishable from the overall conditioning pulse failure rate. It is postulated that the mechanism of paired-pulse facilitation is presynaptic and associated with successful synaptic release in response to the conditioning stimulus.

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More information

Published date: 8 November 1996
Keywords: hippocampus, presynaptic release, paired-pulse facilitation, calcium

Identifiers

Local EPrints ID: 56572
URI: https://eprints.soton.ac.uk/id/eprint/56572
ISSN: 0304-3940
PURE UUID: 2aaebf20-47e4-4556-ac7e-d70de5956d49
ORCID for J.E. Chad: ORCID iD orcid.org/0000-0001-6442-4281

Catalogue record

Date deposited: 22 Aug 2008
Last modified: 14 Mar 2019 01:56

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