The University of Southampton
University of Southampton Institutional Repository

Epidermal transglutaminase (TGase 3) is the autoantigen of dermatitis herpetiformis

Record type: Article

While tissue transglutaminase has been implicated as the major autoantigen of gluten sensitive disease, there has been no explanation as to why this condition appears in two distinct forms, celiac disease and dermatitis herpetiformis. We performed ELISA and immunohistochemical studies to and the difference between the two conditions. Here we show that while sera from patients with either form of gluten sensitive disease react both with tissue transglutaminase and the related enzyme epidermal (type 3) transglutaminase, antibodies in patients having dermatitis herpetiformis
show a markedly higher avidity for epidermal transglutaminase. Further, these patients have an antibody population speci®c for this enzyme. We also show that the IgA precipitates in the papillary dermis of patients with dermatitis herpetiformis, the defining signs of the disease, contain epidermal transglutaminase, but not tissue transglutaminase or keratinocyte transglutaminase. These findings demonstrate that epidermal transglutaminase, rather than tissue transglutaminase, is the dominant autoantigen in dermatitis herpetiformis and explain why skin symptoms appear in a proportion of patients having gluten sensitive disease

Full text not available from this repository.

Citation

Miklos, S., Karpati, S., Merkl, B., Paulsson, M. and Smyth, N. (2002) Epidermal transglutaminase (TGase 3) is the autoantigen of dermatitis herpetiformis Journal of Investigative Dermatology, 119, (1), p. 315.

More information

Published date: 1 July 2002
Additional Information: Abstract number 644

Identifiers

Local EPrints ID: 56616
URI: http://eprints.soton.ac.uk/id/eprint/56616
ISSN: 0022-202X
PURE UUID: bb4c3312-cb7b-4636-ab1b-890f1c8a0fef

Catalogue record

Date deposited: 06 Aug 2008
Last modified: 17 Jul 2017 14:30

Export record

Contributors

Author: S. Miklos
Author: S. Karpati
Author: B. Merkl
Author: M. Paulsson
Author: N. Smyth

University divisions


Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×